期刊文献+

螺内酯对老年慢性心力衰竭患者心功能和血浆脑钠肽的影响 被引量:14

Effect of spironolactone on the cardiac function and plasma brain natriuretic peptide(BNP) in elderly patients with chronic heart failure
下载PDF
导出
摘要 目的探讨螺内酯在老年慢性心力衰竭患者治疗中的作用。方法 62例老年慢性心力衰竭患者根据治疗方法不同分为常规组(30例)和螺内酯组(32例)。常规组:接受ACEI、洋地黄、噻嗪类利尿剂、β受体阻滞剂等常规治疗。螺内酯组:在常规治疗基础上口服螺内酯。观察各组患者在治疗前及治疗后4个月的血清BNP水平、LVEF、VE/VA,观察治疗后1个月的临床疗效。结果螺内酯组治疗后1个月的总有效率(90.6%)明显高于常规组(70%);螺内酯组治疗后LVEF、VE/VA较常规组明显升高(P<0.05)。2组治疗后血清BNP水平均较治疗前明显降低,螺内酯组降低更加明显(P<0.05)。结论螺内酯能明显改善老年慢性心力衰竭患者的心功能,降低血清BNP水平。 Objective To investigate the role of spironolactone in the treatment of chronic heart failure.Methods Sixty-two patients with chronic heart failure were divided into conventional group(n=30) and spironolactone group(n=32).The conventional group received ACEI,digitalis, thiazide diuretics,β-blockers and other conventional treatments.Spironolactone group took oral spironolactone treatment in addition to the conventional treatment.Serum BNP levels,LVEF and VE/VA before and after 4 months of the treatment were observed.The treatment efficacy after 1 month of the treatment was observed as well.Results One month after treatment,the total efficiency(90.6%) of spironolactone group was significantly higher than that of the conventional group(70%).LVEF and VE/VA of spironolactone group were significantly higher than those of the conventional group(P0.05).After treatment,the serum BNP levels of both groups decreased.The spironolactone group had more significant decreases(P0.05).Conclusion Spironolactone can significantly improve cardiac function and decrease serum BNP levels in elderly patients with chronic heart failure.
出处 《实用临床医药杂志》 CAS 2012年第1期74-76,共3页 Journal of Clinical Medicine in Practice
基金 中国高校医学期刊临床专项资金(11120034)
关键词 螺内酯 慢性心力衰竭 心功能 脑钠肽 spironolactone chronic heart failure heart function brain natriuretic peptide
  • 相关文献

参考文献2

二级参考文献20

  • 1尤华彦,吴小庆.重组人脑利尿钠肽辅助治疗慢性充血性心力衰竭273例疗效观察[J].山东医药,2009,49(51):69-70. 被引量:3
  • 2Martin R,Gustavo F.BNP and Congrestive Heart Failure.Prog Cardiovascu Dis 2002,44(4):293-321.
  • 3Oliver P,Fox J,Kin R,et al.Hypertension.cardiac hypertrophy and sudden death in mice lacking natriuretic peptide receptor A.Proc Natl Acad Sci USA,1997,94:14730-14735.
  • 4Tamura N,Ogawa Y,Chusho H,et al.Cardiac fibrosis in mice lacking brain natriuretic peptide.Proc Natl Acad Sci USA,2000,97:4239-4244.
  • 5Elmers L,Knowles J.Ventricular expression of atrial and brain natriuretic peptide in NPR-1 deficientmice with cardiac hypertrophy and fibrosis.Am J Physiol,2002,283:707-714.
  • 6Vicky AC,Leigh J.M inireview,Natriuretic peptides during development of the fetal heart and circulation.Endocrinology,2003,144(6):2191-2194.
  • 7Surakit Nathisuwan,Robert L,Talbert A.Review of vasopeptidase inhibitors a new modality in the treament of hypertension and chronic heart failure.Pharmacotherapy,2002,22(1):27-42.
  • 8Miriam TR,Richard AM.Cardiac natriuretic peptides for cardiac health.Clinical Science,2005,108:23-36.
  • 9Osman R,Alat I,Coskun S,et al.The role of brain natriuretic peptide in the prediction of cardiac performace in coronary artery bypass grafting.Tex Heart Inst J,2003,30:298-304.
  • 10James A,Lemos MD,David A.Morrow MD.Brain natriuretic peptide measurement in actue coronary syndrome:Ready for clinical application.Circulation,2002,106:2868-2870.

共引文献12

同被引文献95

  • 1武蓓,陈红.ACC/AHA关于顽固性心力衰竭的治疗建议[J].中国医药导刊,2005,7(2):146-146. 被引量:5
  • 2任明霞,张茂洪.慢性心力衰竭患者血浆超敏C反应蛋白和N末端脑钠肽原水平变化及意义[J].湖北医药学院学报,2011,30(5):529-530. 被引量:16
  • 3李庆红,李燕燕,许根友.醛固酮拮抗剂治疗慢性心力衰竭的疗效分析[J].中国心血管病研究,2007,5(6):438-439. 被引量:2
  • 4陈灏珠.临床心脏病学[M].上海:上海医科大学出版社,1999:233.
  • 5Narkiewiez K, Catherine A, Philippe JH, et al. Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure[J]. Circulation, 1999,100:262-267.
  • 6Damman K, Voors A, Navis G, et al. The cardiorenal syndrome in heart failure[J]. Prog Cardiovasc Dis, 2011,54(2) : 144.
  • 7Metra M, Bettari L, Carubelli V,et al. Old and new intravenousinot ropic agent s in the treatment of advanced heart failure[J].Prog Cardiovasc Dis, 2011,54(2) :97.
  • 8Campana C.Pasotti M, Klersy C, eta 1.Baseline and 6-month B type natriuretic peptide changes are independent predictors of events in patients with advanced heart failure awaiting car- diac transplantation [ J ].Cardiovase Med, 2009,10 ( 9 ) : 671 - 676.
  • 9Lassus J, HarjoIa M. Cystatin C:a step forward in assessing kidney function and cardiovascular risk [ J ]. Heart Fail Rev,2012,17(2):259-261.
  • 10Kozdag G,Ertas G,Kilic T. Elevated level of highsensitivity C-rcactive protein is important in determining prognosis in chronic heart failure[J].{H}MEDICAL SCIENCE MONITOR,2010,(03):CR156-CR161.

二级引证文献57

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部