摘要
制备了一种新的β-环糊精衍生物固定相2,6-二-O-戊基-3-O-[(甲基)5(烯丙基)2]-β-CD,并对其气相色谱分离性能进行研究。实验显示,该固定相具有良好的柱表面性能和较强的色谱分离能力,对一些芳香族位置异构体的分离能力优于2,6-二-O-戊基-3-O-烯丙基-β-CD衍生物,对10余种手性物质显示出较好的选择性能,且对α-位取代的丙酸酯类手性分离效果明显优于杂环类β-CD衍生物。与2,6-二-O-戊基-3-O-烯丙基-β-CD固定相的分离性能比较表明,β-CD 3位羟基部分甲基基团的引入能增强对芳香族位置异构体的选择能力,但不能明显改变烯丙基衍生物的手性分离能力。
A new β-cyclodextrin（β-CD） derivative,2,6-di-O-pentyl-3-O-[（methyl）5（allyl）2]-β-CD was synthesized.The chromatographic properties of this β-CD derivative were examined and studied by using as a chiral stationary phase in capillary gas chromatography,which showed a good separation ability and a chiral selectivity.Nine kinds of aromatic positional isomers were successfully separated with good resolutions,and parts of their separation results were better than that of 2,6-di-O-pentyl-3-O-allyl-β-CD and other β-CD derivatives.And meanwhile,more than ten kinds of chiral compounds were also determined on this stationary phase.Especially,the separations of some propanoic acid esters with α-substitute were better than those on heterocyclic β-CD derivatives reported in the literature.However,the experimental results showed the chiral separation ability of this stationary phase was still similar to the 2,6-di-O-pentyl-3-O-allyl-β-CD by comparison.It indicated that the introduction of methyl to the part of C3-OH positions may improve the selectivity to aromatic positional isomers,but could not affect obviously the chiral separation ability of the β-CD derivative modified allyl groups on the whole of the C3-OH positions.
出处
《分析测试学报》
CAS
CSCD
北大核心
2012年第2期138-142,共5页
Journal of Instrumental Analysis
基金
国家自然科学基金(81001595)
中央高校基本科研业务费专项资金(中央民族大学科研项目0910KYQN67)
新疆名医名方与特色方剂实验室开放课题(XJDX0910-2010-01)
关键词
毛细管气相色谱
Β-环糊精衍生物
手性分离
capillary gas chromatography
β-cyclodextrin derivative
chiral separation
