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Mimecan/Osteoglycin与心血管疾病 被引量：2

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摘要 Mimecan/Osteoglycin(OGN)是一种细胞外基质蛋白,主要由Osteoglycin基因编码而成,在动脉的生长与发育,在动脉粥样硬化病理生理、心肌细胞的增殖及心脏功能等方面发挥重要作用。
作者 雷军平 曹江晨 郑兴
机构地区 长海医院心血管内科 解放军
出处 《东南国防医药》 2012年第1期52-54,共3页 Military Medical Journal of Southeast China
关键词 心血管疾病 Mimecan
分类号 R541 [医药卫生—心血管疾病]
  • 相关文献

参考文献24

  • 1Funderburgh JL, Corpuz LM, Roth MR, et al. Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene pro- ducing osteoglycin [ J ]. J Biol Chem, 1997,272 ( 44 ) : 28089- 28095.
  • 2Tasheva ES,Pettenati M,Von Kap-Her C,et al. Assignment of mi- mecan gene(OGN) to human chromosome band 9@2 by in situ hy- bridization [ J ]. Cytogenet Cell Genet 2000,88 ( 3 4 ) : 326-327.
  • 3McEwan PA, Scott PG, Bishop PN, et al. Structural corretations in the family of small leucine-rich repeat proteins and proteogly-cans [J]. JStruct Biol,2006,155(2) :294-305. ,.
  • 4Elena S, Tasheva, An Ke, et al. Differentially expressed genes in the lens of mimecan-null mice[ J]. Mol Vis,2004,17(10) :403-416.
  • 5Ge G, Seo NS, Liang X, et al. Bone morphogenetic protein-1/tol- loid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis [ J ]. J Biol Chem,2004, 279(40) :41626-41633.
  • 6Moseley R, Stewart JE, Stephens P, et al. Extracellularmatrix me- tabolites as potential biomarkers of disease activiyin wound fluid lessons learned from other inflammatory diseases[ J]. Br J Derma- tol,2004,150(3) :401-413.
  • 7Shanahan CM, Cary NR, Osboum JK, et al. Identification of osteo- glycin as a component of the vascular matrix : differential expression by vascular smooth muscle ceils during neointima formation and in atherosclerotic plaques [ J]. Arterioscler Thromb Vasc Biol, 1997, 17 ( 11 ) :2437-2447.
  • 8Gu XS,Lei JP,Shi JB,et al. Mimecan is involved in aortic hyper- trophy induced by sinoaortic denervation in rats[ J]. Mol Cell Bio- chem,2011,352(1-2) :309-316.
  • 9Wu-Wong JR, Nakane M, Ma J, et al. VDR-mediated gene expres- sion patterns in resting human coronary artery smooth muscle cells [J]. J Cell Biochem,2007,100(6) :1395-1405.
  • 10Kampmann A, Femandez B, Deindl E, et al. The proteoglycan os- teoglycin/mimecan is correlated with arteriogenesis [ J ]. Mol Cell Biochem,2009,322 ( 1-2 ) : 15-23.

二级参考文献46

  • 1边树怀,高晶,黄希正.胶原代谢异常和高血压[J].河北医科大学学报,2006,27(1):66-68. 被引量：3
  • 2金修才,赵宝珍.颈动脉内中膜厚度的测量及其与心血管危险因素的关系[J].中国医学影像学杂志,2006,14(1):55-57. 被引量：13
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  • 5Twigg SM, Joly AH, Chen MM, et al. Connective tissue tissue growth factor/IGF-bin-ding protein-related protein- 2 is a mediator in the induction of fibronection by advanced glycosylationen, products in human dermal fibroblasts[J]. Endocrinology,2002,143(4) : 1260-1266.
  • 6Ruperez M, Rodrigues-Diez R, Blanco-Colio LM, et al. HMG-CoA reductase inhibitors decrease angiotensin Ⅱ-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways[J]. Hypertension,2007,50(2) :377-383.
  • 7Luo JD,Zhang WW, Zhang GP,et al. Simvastatin inhibits cardic hypertropy and angiotension-converting enzyme activity in rats with aoutic stenosis[J]. Clin Exp Pharmacol Physiol, 1999,26 : 903 - 908.
  • 8Suurkula M,Agewall S,Fagerberg B,et al.Ultrasound evaluation of atherosclerotic manifestations in the carotid artery in high-risk hypertensive patients[J].Arterioscler Thromb,1994,14(5):1297-1304.
  • 9Simonet WS,Lacey DL,Dunstan CR,et al.Osteoprotegerin:a novel secreted protein involved in the regulation of bone density[J].Cell,1997,89(7):309-319.
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共引文献15

同被引文献15

  • 1Tanaka K,Matsumoto E,Kaji H,et al.Role of osteogly cin in the linkage between muscle and bone[J] .J Biol Chem,2012,287(15):11616-11628.
  • 2Gu XS,Lei JP,Shi JB,et al.Mimecan is involved in aortic hypertrophy induced by sinoaortic denervation in rats[J] .Mol Cell Biochem,2011,352(1 ～2):309-316.
  • 3Ge G,Seo NS,Liang X,et al.Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis[J] .J Biol Chem,2004,279 (40):41626-41633.
  • 4Kampmann A,Fernandez B,Deindl E,et al.The proteoglycan osteoglycin/mimecan is correlated with atheriogenesis[J] .Mol Cell Biochem,2009,322(1-2):15-23.
  • 5Kwon HM,Hong BK,Kang TS,et al.Expression of osteopontin in calcified coronary atherosclerotic plaques[J] .J Korean Med Sci,2000,15(5):485-493.
  • 6Borja F,Andreas K,Frederic P,et al.Osteoglycin expression and localization in rabbit tissues and atherosclerotic plaques[J] .Mol Cell Biochem,2003,246 (1-2):3-11.
  • 7Tasheva ES,Pettenati M,Kap-Her C,et al.Assignment of mimecan gene to human chromosome band 9q22 by in situ hybridization[J] .Cytogenet Cell Genet,2000,88(3/4):326-327.
  • 8Ma QY,Zhang XN,Song HD,et al.Mimecan in pituitary corticotroph cells may regulate ACTH secretion and the HPAA[J] .Mol Cell Endocrinol,2011,341 (1-2):71-77.
  • 9Petretto E,Sarwar R,Cook SA,et al.Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass[J] .Nat Genet,2008,40(5):546-552.
  • 10Tasheva ES,Koester A,Conrad GW,et al.Mimecan/osteoglycin-deficient mice have collagen fibril abnormalities[J] .Mol Vis,2002,8:407-415.

引证文献2

东南国防医药
2012年 第1期

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