摘要
目的 探讨不同有氧运动方式对2型糖尿病小鼠血糖和血清胰岛素的影响.方法 将40只C57BL/6J小鼠分为4组：正常组（A组）,糖尿病游泳1组（B组）,糖尿病游泳2组（C组）,糖尿病非运动组（D组）,每组10只.高脂饲料饲养小鼠4周,B组、C组和D组小鼠一次性腹腔注射链脲佐菌素（STZ）,获得糖尿病模型小鼠.B组每日游泳1次,连续游泳90min;C组每日游泳2次,每次45min;B组、C组游泳时间为6周,A组和D组不做游泳运动.血糖仪检测血糖浓度,碘[125I]胰岛素放射免疫分析血清胰岛素的变化.结果 C组血糖浓度明显低于B组和D组[（14.64±2.69）mmol/L,（19.22±3.28）mmol/L,（27.35±2.88）mmol/L,P〈0.05];C组血清胰岛素明显低于D组[（36.95±14.66）mU/L,（55.24±18.42） mU/L,P〈0.05].结论 每日2次各45 min的有氧运动对改善2型糖尿病小鼠血糖及胰岛素水平具有一定疗效.
Objective To compare with the effect of different aerobic exercise on the blood sugar and serum insulin of type Ⅱ diabetes mice. Methods 40 C57BL/6J mice were randomly divided into 4 groups （ n = 10 each） ： the uormal group（group A） ,the swimming group 1 of type Ⅱ diabetes mice （group B） , the swimming group 2 of type Ⅱ diabetes mice （ group C） , the no swimming group of type Ⅱ diabetes mice （D）. The diabetes mice were fed with high - sugar and highfat diets for 4 weeks, and each one was injected intraperitoneally with streptozotocin（STZ） once to get the type Ⅱ diabetes mice. The mice of group B were made to swim for 90 min once every day, while the group C to swim for 45 min twice a day, and the blood sugar and serum insulin were measured after 6 weeks. Results Blood sugar of group C was lower than group B and C obviously [ （ 14.64 ± 2.69 ） mmol/L, （ 19.22 ± 3.28 ） mmol/L, （ 27.35 ± 2.88 ） mmol/L, P 〈 0.05]. Serum insulin of group C was lower than group D apparently[ （36.95 ± 14.66） mU/L, （55.24± 18.42） mU/L,P 〈 0.051. Conclusion Swimming for 45 min twice a day is good for adjusting blood sugar and insulin levels
出处
《徐州医学院学报》
CAS
2012年第1期51-53,共3页
Acta Academiae Medicinae Xuzhou
基金
基金项目：徐州市社会发展科学基金（XM098116）,徐州医学院科研基金（08KJ47）
关键词
2型糖尿病
有氧运动
血糖
胰岛素
小鼠
typeⅡ diabetes
aerobic exercise
blood sugar
serum insulin
mice
