摘要
目的:分析我院药品不良反应(ADR)发生的特点和相关因素,为临床合理用药提供参考。方法:对我院2009年9月-2011年10月所收集的390例ADR报告进行回顾性分析。结果:在390例ADR报告中,女性(236例)多于男性(154例),以≥50岁的中老年人与≤18岁的未成年人发生率居高。在给药方式中,静脉滴注引发的ADR最多(占86.67%)。在ADR涉及的药品种类及例/次中,抗菌药物居首位(占70.00%),其次是中药及中药制剂(占11.03%)。ADR临床表现以皮肤及其附件损害最为常见(占41.79%)。结论:我院ADR的发生与患者性别、年龄、给药途径、药品种类等相关;临床应加强合理使用抗菌药物及中药注射剂,以减少和避免ADR的发生。
OBJECTIVE： To analyze characteristics and relative factors of adverse drug reactions （ADR） occurred in our hospital, and to provide reference for rational drug use in the clinic. METHODS： A total of 390 ADR cases collected from Sept. 2009 to Oct. 2011 in our hospital were analyzed retrospectively. RESULTS： In the 390 ADR cases, females （236 cases） were more than males （154 cases）, and patient aged ≤ 18 and ≥50 had significantly high incidence. Among route of administrations, 86.67% of the ADR cases were induced by intravenous drip. Among drug types and case number of ADR cases, antimicrobial agents took up the first place （70.00 % ）, followed by traditional Chinese medicine and TCM preparations （11.03% ）. Additionally, the most common manifestation of ADR was lesion of skin and its appendants （41.79%）. CONCLUSIONS： The occurrence of ADR cases in our hospital is related with patient＇ s gender, age, route of administration, and drug type. Rational use of antimicrobials and TCM injection should be strengthened so as to lessen and avoid the occurrence of ADR.
出处
《中国药房》
CAS
CSCD
2012年第10期922-924,共3页
China Pharmacy
