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中国骨肉瘤事业的传承和发展 被引量:8

The inheritage and development of the treatment for osteosarcoma in China
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摘要 1959年我从协和医院调到中国医学科学院肿瘤医院(当时叫日坛医院),开始从事肿瘤治疗的临床和实验研究工作.当时正值"大跃进"时期,提出的豪迈口号是:"让高血压低头,肿瘤让路."当初的条件很差,只能一边起步一边摸索,想着如何能开辟新径、突破瓶颈,让更多的肿瘤患者受益. In the 1950s, operation was introduced to treat osteosarcoma in China which could be seen as the beginning of the treatment of osteosarcoma. In 1970's, Jaffe began to use high-dose methotrexate and leucovorin (MTX-CF) in the treatment of lung metastasis of osteosarcoma, marking the beginning of adjuvant chemotherapy for osteosarcoma. Since then, Rosen designed a preoperative chemotherapy which was considered as neoadjuvant chemotherapy. China developed a suitable chemotherapy for osteosarcoma in 1980's. Therefore, the chemotherapy for osteosarcoma in China kept pace with the world. In the past 30 years, with hard work of several generations, the 5-year survival rate and limb salvage rate of osteosarcoma patients in China increased gradually, with international standards of academic development. In 2010, 4 American academic authorities released a report that the incidence and mortality of cancer, particularly tumors in children, have declined in recent years in the states. Bottlenecks existed in the progress of osteosarcoma in China, such as the unbalanced regional development, the lack of unified standard in the treatment of osteosarcoma and the lack of professionals. We recognized our shortcomings and improved them continuously. Conventional cytotoxic regents for osteosarcoma develop very slowly recently, but a variety of molecular targeted therapies worked in the treatment of bone and soft tissue sarcoma, demonstrating a certain prospect in the future. As our motherland continues thriving, the treatment of osteosarcoma in China will develop rapidly, which would allow to benefit osteosarcoma patients in China.
作者 孙燕
出处 《中国骨与关节杂志》 CAS 2012年第1期1-3,共3页 Chinese Journal of Bone and Joint
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