摘要
目的 观察 3 7例自身免疫性甲状腺病 (AITD)患者甲状腺组织中相关白细胞介素 (IL)及受体基因表达 ,并测定血清TT3、TT4及TGA、TMA的水平 ,结果表明格莱弗氏病 (GD)患者IL - 2、IL - 2R及IL - 6mRNAA表达细胞阳性率与血清TT3、TT4水平呈正相关。桥本氏甲状腺炎 (HT)患者IL - 2、IL - 2R、IL - 6mRNA表达细胞阳性率与血清TGATMA呈正相关。这两者相关关系的差异 ,提示二者存在不同的免疫发病机制。
IL-2, IL-2R, and IL-6 mRNA expression in situ thyroid were determined, and serum TT 3, TT 4, TGA, and TMA were measured by Elisa in 37 patients with autoimmune thyroid disease. In Graves disease (GD), the positive rates of IL-2, IL-2R and IL-6 mRNA were significantly correlated with TT 3, TT 4 levels. In Hashimoto thyroiditis (HT), the positive rates were significantly correlated with serum TGA and TMA levels. It is suggested that GD and HT has different immune pathogenesis.
出处
《云南医药》
CAS
2000年第1期2-4,共3页
Medicine and Pharmacy of Yunnan
基金
美国中华医学基金
