摘要
目的探讨2型糖尿病者(T2DM)和健康对照者(NC),糖尿病肾病者(DN)和糖尿病非肾病者(NDN)血浆胰高血糖素样肽-1(GLP-1)水平的差异.方法选择144例云南汉族人群为研究对象,包括2型糖尿病患者86例〔其中55例糖尿病无肾病(NDN),30例糖尿病肾病(DN)〕,为T2DM组,健康对照者59例,为NC组.采用EIA法测定空腹GLP-1浓度,比较不同组别之间血浆GLP-1水平的差异.结果 T2DM患者空腹血浆GLP-1浓度低于NC者,[(3.83±6.84)pmol/L vs(2.78±2.95)pmol/L,P<0.05];NDN患者与DN患者空腹血浆GLP-1浓度差异无统计学意义[(2.68±2.57)pmol/L vs(2.96±3.58)pmol/L,P=0.665].血浆GLP-1水平与HDL-C呈正相关,与年龄呈负相关.结论血浆GLP-1水平的降低可能是2型糖尿病的危险因素,而GLP-1水平增高有可能在2型糖尿病患者大血管并发症的发生中发挥作用.年龄的增长引起GLP-1浓度下降可能为T2DM的发病机制之一.
Objective To investigate the plasma concentration of Glucagon-Like Peptide 1 （GLP-1） in type 2 diabetes patients （T2DM） , normal controls （NC） , diabetic nephropathy （DN） and diabetic non-nephropathy （NDN）. Methods We recruited 86 T2DM patients in Yunnan Han population （ including 55 NDN cases and 30 DN cases） and 59 normal controls （NC group）. Fasting plasma level of GLP-1 was measured by Enzyme linked immunosorbent assay （EIASA） method. Results T2DM patients had significant lower GLP-1 level than controls [ （3.83±6.84） pmol/l vs （2.78 ±2.95） pmoU1, P = 0.025]. The difference of the fasting plasma GLP-1 between NDN and DN patients was not statistically significant [ （2.68±2.57） pmol/1 vs （2.96±3.58） pmol/L, P = 0.665 ]. GLP-1 level was positively correlated with HDL-C and was negatively correlated with age. Conclusions Fasting plasam GLP-1 level might be a risk factor for T2DM.GLP-1 level may play a role in the pathogenesis of macrovascular complications in T2DM. Aging-related reduced GLP-1 may be one of the pathway involving in T2DM.
出处
《昆明医学院学报》
2012年第1期90-93,共4页
Journal of Kunming Medical College
关键词
2型糖尿病
糖尿病肾病
胰高血糖素样肽-1
Type 2 diabetes mellitus
Diabetic nephropathy
Glucagon-like peptide-1
