摘要
目的：探讨混合性结缔组织病（ＭＣＴＤ）患者临床特点与病程的相关性。方法：对明确诊断ＭＣＴＤ的３０例住院病例进行了回顾性分析。将其分为两组：Ａ组病程〈５年，Ｂ组病程≥５年。结果：ＭＣＴＤ首发症状主要为雷诺现象，关节痛／关节炎等，其临床表现Ａ组雷诺现象发生率非常显著高于Ｂ组，而后者肺动脉高压／肺间质纤维化发生率显著增加。
Objective:To evaluate the clinical features and correlation with disease course of mixed connective tissue disease (MCTD).Methods:30 patients with definite MCTD were analyzed retropectively by their clinical manifestation and immunological features,treatments and prognosis.They were assigned to two groups according to their courses of the disease (group A<5 years and group B ≥5 years).Results:The primarily incipient symptoms of MCTD were Raynaud's phenomenon and arthralgia/arthritis.Morbidity of Raynaud's phenomenon in group A was statistically significantly higher than in group B(P<0.01) while incidence of pulmonary hypertension or interstitial fibrosis was higher in group B (P<0.05).Laboratroy indices showed that abnormal IgG and ESR were easy to be seen and renal dysfunction with high uria protein was found in 26.7% patients.Mortality was zero in group A while 25% in group B.Conclusion:MCTD is not a benign disease.With disease duration prolonged,incidence of vital organ dysfunction increases and mortality tends to elevate.
出处
《医师进修杂志》
2000年第3期26-28,共3页
Journal of Postgraduates of Medicine
关键词
临床分析
病程
胶原病
MCTD
症状
诊断
治疗
mixed connective tissue disease(MCTD)
clinical analysis
disease course
