摘要
【目的】研究干地黄胃粘膜快速保护作用及机制。【方法】在给无水乙醇之前或之后立即给予干地黄煎剂或提取物A ,观察其保护胃粘膜免受损伤的作用 ,并用不同浓度辣椒辣素预处理以分析其保护机制。【结果】①胃饲 6g·kg-1干地黄煎剂或提取物A均能显著保护胃粘膜免受随后给予无水乙醇 2mL所致的损伤 ;②先给予无水乙醇 ,后胃饲干地黄煎剂或提取物A则无保护作用 ;③先给予 φ =70 %乙醇 2mL ,后给予干地黄煎剂 6g·kg-1,保护效应又再出现 ;④先胃饲无水乙醇 ,后经十二指肠注射 12 g·kg-1提取物A亦能显著减轻胃粘膜损伤 ;⑤分别用 10 0 g·L-1、40 0 g·L-1和 80 0 g·L-1的辣椒煎剂预处理大鼠 ,提取物A的胃粘膜保护作用随着辣椒辣素给药剂量的增大明显减弱直至消失。【结论】干地黄对胃粘膜有快速保护作用 ,其机制可能与胃粘膜内辣椒辣素敏感神经元传入冲动增多有关。
Objective To study the immediate protective effects and its mechanism of the dry Radix Rehmanniae (DRR) on gastric mucosa. Methods The decoction or extract A of DRR was given orally into rats before or after absolute ethanol to observe the protective effects on gastric mucosal damage. The rats were pretreated with the different concentrations of capsaicin to analyze the protection mechanism. Results ① The 6 g·kg -1 decoction or extract A of DRR, which was administered orally, protected markedly the gastric mucosa from damage induced by 2 mL absolute ethanol given soon afterwards. ② The absolute ethanol was administered orally, then the 6 g·kg -1 decoction or extract A of DRR was followed instantly, the protective effect did not occur. ③ When the 6 g·kg -1 decoction of DRR was administered orally following closely 2 mL φ=70% ethanol, the protective effect did occur again. ④ The 12 g·kg -1 extract A injected into duodenum after absolute ethanol given orally, reduced markedly gastric mucosa damage too. ⑤ Pretreatment with the 100 g·L -1 , 400 g·L -1 and 800 g·L -1 decoction of chilli (dried fruit of capsicum) to rats respectively, the protective effects of extract A on gastric mucosa were reduced gradually to nil in a dose dependent manner. Conclusions The DRR possesses an immediate protection on gastric mucosa, the mechanism of it may be mediated by increasing afferent impulses of capsaicin sensitive neurons in gastric mucosa.
出处
《中山医科大学学报》
CSCD
2000年第2期133-136,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
广东省中医药管理局科研基金! ( 983 80 )
关键词
胃粘膜
药物作用
地黄
辣椒辣素
gastric mucosa/drug effects
rehmannia glutinosa/therapeutic use
capsaicin
alcohol, ethyl
