摘要
目的观察加味四君子汤对烧伤患者血清清蛋白(ALB)和前清蛋白(PA)含量的影响。方法采用随机对照法将50例30%～50%全身性烧伤面积(TBSA)患者分为治疗组与对照组,分别服用加味四君子汤和等量生理盐水10d,观察患者消化功能,检测治疗前、治疗开始后1～10d血清ALB和PA含量。结果治疗组和对照组消化功能恢复的临床表现分别为16例(64%)和10例(40%)显效,两组比较差异有统计学意义(P<0.05)。对照组治疗期间血清PA和ALB含量持续下降,至治疗开始后10dPA为(97.11±2.84)mg/L、ALB为(28.04±1.62)mg/L,分别较开始前下降52.95%和20.23%。而治疗组服药后4～7d血清PA和ALB含量逐渐升高,至治疗开始后10dPA为(253.41±6.07)mg/L、ALB为(43.31±2.46)mg/L,达到正常值范围,与对照组比较差异有统计学意义(P<0.01)。结论加味四君子汤能改善烧伤患者消化功能,提高血清ALB和PA含量,值得临床推广应用。
Objective To observe the effect of modified Sijunzi Decoction on the serum content of albumin（ALB） and prealbumin（PA） in burn patient.Methods Fifty burn patients with 30%-50% total body surface area（TBSA） were randomly divided into the treatmant group and the control group.Based on the conventional therapy for two groups,Sijunzi Decoction 100mL or normal saline 100mL were taken orally twice a day respectively.The therapeutic course was 10 d.Before and after treatment,the improvement of digestive function was observed,at the same time the serum contents of ALB and PA were measured.Results After therapy,there were 16 cases（64%） in the treatment group and 10 cases（40%） in the control group showing the distinct improvement of digestive function（P0.05）.The contents of ALB and PA in serum were decreased significantly in the control group during treatment,the rate of decline was 52.95% and 20.23% respectively.But the contents of ALB and PA in serum were increased in the treatment group from 4-7 d after taking Sijunzi Decoction,at the end of therapeutic course PA reaching（253.41±6.07）mg/L,ALB reaching（43.31±2.46）mg/L,there had significant difference in the serum contents of ALB and PA between the control group and treatment group（P0.01）.Conclusion Modified Sijunzi Decoction in treating burn could effectively raise the contents of ALB and PA in serum and improve the digestive function of burn patients,which is worth being popularized in clinic.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第5期449-450,452,共3页
Chongqing medicine
