摘要
目的 研究血管内皮生长因子 (VEGF)表达与胶质瘤微血管数、肿瘤增殖活性及其与胶质瘤恶性程度的相关性。方法 应用免疫组化方法检测 5 0例胶质瘤、8例正常脑组织中VEGF、血小板内皮细胞粘附分子 (CD3 1)和增殖细胞核抗原 (PCNA)的表达 ,测定其阳性细胞数和阳性血管数。结果 胶质瘤中均有VEGF、CD3 1及PCNA表达。其表达水平与肿瘤恶性程度呈显著正相关 ,其r分别为 0 .745 ,0 .765及 0 .685。结论 VEGF、CD3 1和PCNA在胶质瘤中的高表达是胶质瘤恶性表型之一 ,可作为病理诊断的补充。
Objective To study the expression of VEGF, CD31 and PCNA in gliomas and its relationship to the grade of gliomas.Methods The expression of VEGF, CD31 and PCNA was detected in 8 normal brain tissues and 50 cases of glioma with immunohistochemical method. Results VEGF, CD31 and PCNA were expressed in all gliomas examined and the expression of VEGF, CD31 and PCNA had positive correlation with the grade of gliomas.Conclusions Overexpression of VEGF, CD31 and PCNA is one of the markers of malignant phenotype and pathologic diagnosis of gliomas, which is important to evaluate the patient’s prognosis and select suitable therapy.
出处
《中国神经精神疾病杂志》
CSCD
北大核心
2000年第2期93-95,共3页
Chinese Journal of Nervous and Mental Diseases
关键词
脑肿瘤
胶质瘤
VEGF
CD31
增殖细胞核抗原
Glioma Vascular endothelial growth factor CD31 Proliferating cell nuclear antigen
