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乙型肝炎病毒前S1抗原检测的临床应用价值 被引量:4

Clinical application value of pre-S1 antigen detection for hepatitis B virus
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摘要 目的探讨乙型肝炎病毒前S1抗原与病毒复制的相关性。方法采用酶联免疫吸附试验(ELISA)和荧光定量(PCR)检测100例乙型肝炎患者血清的前S1抗原、乙型肝炎病毒e抗原(HBeAg)和乙型肝炎病毒脱氧核糖核酸(HBV-DNA)。结果 100例乙型肝炎患者标本中,前S1抗原78例阳性,阳性率为78%;HBV-DNA 86例阳性,阳性率为86%;HBeAg 56例阳性,阳性率为56%,在56例HBeAg阳性中,前S1抗原阳性例数为44例,阳性率为78%,HBV-DNA的阳性例数为49例,阳性率为88%,前S1抗原与HBV-DNA的差异性用χ2检验差异无统计学意义(P>0.05)。在86例HBV-DNA阳性中,前S1抗原阳性例数为74例,阳性率为86%,HBeAg阳性例数为50例,阳性率为58%,前S1抗原与HBeAg的检测结果用χ2检验差异有统计学意义(P<0.05)。结论乙型肝炎病毒前S1抗原与HBV-DNA高度相关,是乙肝病毒在体内复制的可靠指标。 Objective To investigate the relativity between pre-S1 antigen of hepatitis B virus with viral replication. Methods ELISA and the fluorescence quantitative PCR were used to detect the pre-S1 antigen level,HBeAg and HBV-DNA in 100 cases of hepatitis B. Results Among 100 samples in 100 cases of hepatitis B,pre-S1 antigen was positive in 78 cases(78%),HBV-DNA was positive in 86 cases(86%) and HBeAg was positive in 56 cases(56%).Among 56 cases of positive HBeAg,pre-S1 was positive in 44 cases(78%) and HBV-DNA was positive in 49 cases(88%),showing that no statistical difference existed between pre-S1 and HBV-DNA(P0.05).Among 86 cases of positive HBV-DNA,pre-S1 antigen was positive in 74 cases(86%) and HBeAg was positive in 50 cases(58%),showing statistical difference between pre-S1 antigen and HBV-DNA(P0.05). Conclusion PreS1 is highly related with HBV-DNA,which is a reliable indicator for in vivo replication of hepatitis B virus.
出处 《检验医学与临床》 CAS 2012年第4期411-412,共2页 Laboratory Medicine and Clinic
关键词 乙型肝炎 前S1抗原 乙型肝炎病毒 hepatitis pre-S1 antigen hepatitis B virus
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