摘要
目的比较Miccoli术式和传统的甲状腺切除术在围手术期细胞因子及应激反应指标的水平，术后需要镇痛例数及对切口满意程度，以证明Miccoli术式是一种值得推广的微创手术。方法将50例随机分为Miccoli：术式（MO）组和传统术式（RO）组，分别在麻醉前、麻醉后、切皮后1h、术后第1、2、3天6个时段抽取血样监测白细胞介素6（IL-6），白细胞介素-8（IL-8）、皮质醇（CORT）、C反应蛋白（CRP）。记录手术时间、术后需要镇痛例数，比较2组对切口的满意程度。结果2组的各项指标在手术开始后呈现上升趋势，并在术后第1天达到峰值，随后逐渐下降。各项指标在切皮后1h、术后第1、2、3天MO组明显低于RO组，差异有统计学意义（P〈0．05）。手术时间MO组长于RO组，差异有统计学意义（P〈0．05）。2组需镇痛例数相比，MO组明显少于RO组，对切口的满意程度MO组明显高于RO组，差异有统计学意义（P〈0．05）。结论Miccoli术式与传统甲状腺切除术相比，手术创伤小，机体恢复快，是值得推广的一种微创手术。
Objective To compare perioperative cytokine levels, stress index, postoperative analgesic requirement, as well as the satisfaction of incision between Miccoli＇s thyroidectomy and conventional thyroidectomy. Methods Fifty patients were randomly divided into 2 groups ： Miccoli thyroidectomy group （MO） and conventional thyroidectomy group （ RO ）. The changes of interleukin-6 （ IL-6 ） , intedeukin-8 （ IL-8 ） , eortisol （CORT） and C-reactive protein （CRP） were detected before and after anesthesia, 1 hour after skin incision, the 1 st, 2nd and 3rd day after surgery. The operation time, postoperative analgesic requirement, as well as the satisfaction of incision between Miccoli thyroidectomy and conventional thyroideetomy were recorded. Results The level of markers in the 2 groups started to increase after anesthesia and reached the peak on the 1st day after operation, then subsequent decrease of these markers was observed. The level of markers was lower in MO group than in RO group on 1 hour after skin incision, the 1st, 2nd and 3rd day after the operation. The difference had statistical significance（ P 〈0.05 ）. MO group cost longer operative time than RO group and the difference had statistical significance（P 〈 0.05 ）. Less patients in MO group required analgesics. Patients in MO group were more satisfied with the surgical incision（P 〈 0.05 ）. Conclusion Compared with conventional thyroidectomy, Miccoli＇s thyroidectomy is less 1traumatic. It is beneficial for postoperative recovery.
出处
《中华内分泌外科杂志》
CAS
2012年第1期51-53,共3页
Chinese Journal of Endocrine Surgery
