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前列地尔联合胰激肽原酶对早期糖尿病肾病UAER及血流动力学的影响 被引量:3

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摘要 目的:观察应用前列地尔联合胰激肽原酶对早期糖尿病肾病(EDN)患者肾功能及尿蛋白排泄率(UAER,uri-naryalbuminexcretionrates)及血流动力学的影响。方法:将120例EDN患者随机分为治疗组(前列地尔10μg每日1次静点,联合胰激肽原酶240U,每日3次口服)和对照组(前列地尔10μg每日1次静点)。比较两组治疗前后尿白蛋白排泄率(UAER),胆固醇(TC),三酰甘油(TG),肌酐清除率(Ccr)及血流动力学指标变化。结果:治疗组及对照组UAER、血脂、Ccr血液流变学等相关指标治疗前后对比差异均有统计学意义(P<0.05)。治疗组与对照组疗效间对比,治疗组优于对照组,差异有统计学意义(P<0.05)。治疗前后尿素氮对比无差异(P>0.05)。治疗组与对照组疗效间对比,差异无统计学意义(P>0.05)。结论:前列地尔与胰激肽原酶联合治疗EDN较单独静点前列地尔更能有效地改善血流动力学指标,降低尿蛋白,保护肾功能。
出处 《中国当代医药》 2011年第36期69-70,共2页 China Modern Medicine
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二级参考文献2

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