摘要
目的探讨乳腺癌术后化疗患者癌因性疲乏与疾病特征的相关性问卷。方法采用便利抽样方法,随机抽取长沙市湘雅医院的200例乳腺癌化疗患者进行癌因性疲乏和疾病特征问卷调查。结果乳腺癌化疗患者总疲乏发生率为100%,躯体疲乏发生率为100%,情感疲乏发生率为98.5%,认知疲乏发生率为99.5%;总疲乏得分为(26.875±6.433),各疲乏维度得分由高到低依次为躯体疲乏(12.990±4.154)、情感疲乏(7.135±2.584)和认知疲乏(6.750±2.433);有并发症患者的总疲乏、躯体疲乏、情感疲乏得分均高于无并发症的患者(P<0.05);贫血患者的总疲乏高于无贫血患者(P<0.05);TAC/TEC/TA化疗组躯体疲乏得分在3组中最高(P<0.05);TAC/TEC/TA化疗组情感疲乏得分高于CAF/CEF化疗组(P<0.05);化疗后第1周患者的情感疲乏高于化疗后第3周患者(P<0.05);化疗后第3周、化疗后第2周、TAC/TEC/TA化疗方案等因素对总疲乏有影响,这3个因素可解释总疲乏的33%;化疗第4疗程、贫血、化疗后第3周、复发转移等因素对躯体疲乏有影响,这4个因素可解释躯体疲乏的31%;化疗后第3周、乳腺癌Ⅱ期、TAC/TEC/TA方案、并发症等因素对情感疲乏有影响,这4个因素可解释情感疲乏的47%;贫血对认知疲乏有影响,这个因素可解释认知疲乏的41%。结论乳腺癌化疗患者普遍存在癌因性疲乏。在疾病特征诸因素中,化疗后第3周、化疗后第2周、TAC/TEC/TA方案、化疗第4疗程、贫血、复发转移、乳腺癌Ⅱ期、并发症是影响癌因性疲乏的主要因素。
[Objective] To study that breast cancer patients with chemotherapy cancer related fatigue levels associated with disease characteristics. [Methods] By Convenient random sampling method, random 200 cases of breast cancer patients treated with chemotherapy for cancer related fatigue and disease characteristics of the investigation in Changsha Xiangya Hospital. [Results] Breast cancer chemotherapy patient of total fa- tigue incidence rate is 100%; physical fatigue incidence rate is 100%, emotional fatigue incidence rate was 98.5%; cognitive fatigue incidence rate is 99.5%; Total fatigue score （26.875±6.433）, the fatigue scores in descending order of physical fatigue （12.990±4.154）, emotional fatigue （7.135±2.584）, cognitive fatigue （6.750± 2.433）; Patients with complications associated with of total fatigue, physical fatigue, emotional fatigue is higher than in patients without complications （P〈0.05）; The total fatigue in patients with anemia is higher than in patients without anemia （P 〈0.05）; TAC/TECFFA chemotherapy group physical fatigue score is the highest in the three groups （P 〈0.05）; TAC/TEC/TA chemotherapy group emotional fatigue is higher than the CAF/CEF chemotherapy group （P 〈0.05）; The first week after chemotherapy in patients with greater emotional fatigue than the third week after chemotherapy in patients （P 〈0.05）; The third week after chemotherapy group, the secondweek after chemotherapy group, TAC/TEC/TA chemotherapy plan is the total fatigue influential factors, which three factors could explain the total fatigue about 33%; The fourth course of chemotherapy, anemia,the third week after chemotherapy, breast cancer recurrence and metastasis are the factors that affect the physical fatigue, and other factors affect fatigue on the body, these four factors explain physical fatigue about 31%; The third week after chemotherapy, the stage II of breast cance, TAC/TEC/TA chemotherapy plan, complications are the factors that affect the emotional fatigue,, these four factors explain the emotional fatigue about 47%; anemia is the factor of cognitive, this factor could explain the cognitive fatigue about 41%. [Conclu- sion] Prevalent in patients with breast cancer chemotherapy. The third week after chemotherapy, the second week after chemotherapy, TAC/TEC/TA chemotherapy, the fourth course of chemotherapy, anemia, the breast cancer recurrent and metastatic, the 1I stage breast cancer, complications in patients with breast cancer chemotherapy were major factors in the disease characteristics.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第35期4443-4449,共7页
China Journal of Modern Medicine
基金
湖南省科技厅科研课题(No:08SK3106)
关键词
乳腺癌
化疗
癌因性疲乏
疾病特征
breast cancer
chemotherapy
cancer related fatigue
disease characteristics
