摘要
目的观察舍曲林治疗偏头痛临床疗效和不良反应。方法收集54例偏头痛患者,接受可变剂量的舍曲林治疗2周。在治疗前和治疗后第1、2周末分别采用症状自评量表(SCL-90)躯体化因子和临床总体印象量表(CGl-SI)评定,用不良反应症状量表(TESS)评定并记录药物的不良反应。结果治疗2周后SCL-90躯体化因子评分和CGI-SI评分较治疗前明显降低,差异有统计学意义(P<0.01);TESS评分,治疗1周时为2.5±1.2,治疗两周时为4.2±2.3;常见的不良反应为头晕、嗜睡、食欲下降等,但程度较轻。结论舍曲林治疗偏头痛的疗效肯定,不良反应少,安全性、依从性好。
Objective To observe the clinical efficacy and side effects of sertraline in the treatment of migraine.Methods fifty four patients with migraine were assigned to receive sertraline for two weeks.The patients were measured with clinical global impression scale(CGI-SI) and somatization in symptom checklist 90(SCL-90) before treatment and at lth,2th weekend after treatment.Then the treatment emergent symptoms scale(TESS) was used to assess the side effects at lth,2th weekend after treatment.Results The score of SCL-90 somatoform gene and the CGI-SI score were all declined after treatment,thus there was significant difference before and after treatment(P0.01).The common side effects of sertraline were headache,decreasing food appetite,hyperinsomnia and so on.Conclusion Sertraline is an effective and safe drug to treat the patients with migraine.
出处
《湖北民族学院学报(医学版)》
2011年第4期26-28,共3页
Journal of Hubei Minzu University(Medical Edition)
关键词
舍曲林
偏头痛
躯体因子评分
Sertraline
migraine
somatization in symptom checklist