1Takahashi K, Yamao K, Okubo K, et al. Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA [J]. Gastrointest Endosc, 2005,61 ( 1 ) :76-79.
2Dbritz J, Preston R, H nfler J, et al. Follow-up study of K-ras Mutations in the plasma of patients with pancreatic cancer [ J]. Pancreas, 2009,38 (5) :534-541.
3Kim J, Reber HA, Dry SM, et at. Unfavourable prognosis associated with K-ras gane mutation in pancreatic cancer surgical margins [ J]. Gut, 2006,55 ( 11 ) : 1598-1605.
4Dong M, Nio Y, Yamasawa K, et al. p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer [ J ]. Journal of Surgical Oncology, 2003,82(2) :111-120.
5Habbe N, Koorstra JB, Mendell JT, et al. MicreRNA miR-155 is a biomarker of early pancreatic neoplasia [ J ]. Cancer Biol Ther, 2009,8(4) :340-346.
6Szafranska AE, Doleshal M, Edmunds HS. Analysis of micreRNAsin pancreatic fine-needle aspirates can classify benign and malignant tissues [J]. Clin Chem, 2008,54(10) :1716-1724.
7Bloomston M, Frankel WL, Petrocca F, et al. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis [ J ]. JAMA, 2007,297 ( 17 ) : 1901-1908.
8Hashimoto Y, Murakami Y, Uemura K, et al. Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer [ J ]. Surgery, 2008,143 (1) :113-125.
9Nakashima A, Murakami Y, Uemura K, et al. Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy [ J ]. Pancreas. 2009.38 (5) :527-533.
2Saif MW.Pancreatic cancer:highlights from the 42nd annual meeting of the American Society of Clinical Oncology,2006[J].JOP,2006,7(4):337-348.
3Ni X,Long J,Cen P,et al.Pancreatic cancer tumour initiating cells:the molecular regulation and therapeutic values[J].J Cell Mol Med,2012,16(5):988-994.
4Siegel R,Ma J,Zou Z,et al.Cancer statistics,2014[J].CA Cancer J Clin,2014,64(1):9-29.
5Burris HA 3rd,Moore MJ,Andersen J,et al.Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer:a randomized trial[J].J Clin Oncol,1997,15(6):2403-2413.
6Kwak PB,Iwasaki S,Tomari Y.The microRNA pathway and cancer[J].Cancer Sci,2010,101(11):2309-2315.
7Gregory RI,Yan KP,Amuthan G,et al.The Microprocessor complex mediates the genesis of microRNAs[J].Nature,2004,432(7014):235-240.
8Bohnsack MT,Czaplinski K,Gorlich D.Exportin 5 is a Ran GTPdependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs[J].RNA,2004,10(2):185-191.
9Yi R,Qin Y,Macara IG,et al.Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs[J].Genes Dev,2003,17(24):3011-3016.
10Garzon R,Marcucci G,Croce CM.Targeting microRNAs in cancer:rationale,strategies and challenges[J].Nat Rev Drug Discov,2010,9(10):775-789.