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不同方法检测葡萄糖-6-磷酸酶缺乏的结果分析 被引量:5

Comparative analysis on detection of glucose-6-phosphatase deficiency by two different methods
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摘要 目的对G6PD缺乏的不同检测方法进行比较和评价。方法以分光光度计比色法、全自动生化分析仪速率法分别对3052例来我院婚检和产检人群进行G6PD检测。结果 3052例受检者中,经分光光度计比色法共检出G6PD缺乏者226例,检出率为7.4%;其中男性152例,检出率为7.9%,女性71例,检出率为6.3%。全自动生化分析仪速率法检出287例,检出率为9.4%;其中男性182例,检出率为9.5%,女性105例,检出率为9.3%。结论全自动生化分析仪速率法测定G6PD与分光光度计比色法均能很好地检测G6PD缺乏患者,前者的检出率更高,操作便捷快速,更易标准化。 Objective To compare and evaluate the results of applying two different methods in glucose-6-phosphatase (G6PD) deficiency detection. Methods 3 052 blood samples were detected by Spectrophotometer assay and Automatic Chemistry analyzer, respectively. Results Of the 3 052 blood samples, 226 cases (7.4%) were detected with G6PD deficiency by Spectrophotometer assay, including 152 males (7.9%) and 71 females (6.3%). By Automatic Chemistry Analyzer, 287 cases (9.4%) were detected with G6PD deficiency, including 182 males (9.5%) and 105 females (9.3%). Conclusion Automatic Chemistry Analyzer and Spectrophotometer assay can both detect G6PD deficiency well, but the former is found with a higher detection rate and easy operation, which is easier to be standardized.
出处 《海南医学》 CAS 2012年第5期80-81,共2页 Hainan Medical Journal
关键词 G6PD缺乏 分光光度计比色法 全自动生化分析仪速率法 G6PD deficiency Automatic chemistry analyzer Spectrophotometer assay
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  • 1Kaplan M, Hammerman C. Neonatal screening for glucose-6-phosphate dehydrogcnase deficiency: biochemical versus genetic technologies [J]. Scmin Perinatol, 2011, 35(3): 155-161.
  • 2杜晓晨,罗建明.G6PD缺乏症杂合子检测方法的研究进展[J].中国小儿血液与肿瘤杂志,2007,12(2):92-94. 被引量:15
  • 3Reclos GJ, Hatzidalds C J, Schulpis KH. Glueose-6-phosphate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficient female neonates are missed during routine screening [J]. J Med Screen. 2000, 7(1): 46-51.

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