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抑凋亡蛋白Survivin及P-糖蛋白在骨肉瘤中的表达与骨肉瘤化疗耐药性关系的研究 被引量:3

Expression of Survivin and P-glycoprotein in osteosarcoma and its relationship with chemoresistance
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摘要 目的探讨抑凋亡蛋白Survivin及多药耐药基因mdr1表达的P-糖蛋白(P-gp)的表达与骨肉瘤临床病理特征间的关系。方法应用免疫组织化学技术(SP法)检测34例骨肉瘤组织及30例骨软骨瘤(对照组)组织中抑凋亡蛋白Survivin及多药耐药基因mdr1表达的P-糖蛋白的表达,统计分析Survivin、P-gp在骨肉瘤组织中表达的相关性和其表达情况与病例临床特征的相关性。结果①34例骨肉瘤组织标本中19例Survivin蛋白表达阳性为55.9%(19/34),27例P-gp表达阳性为79.4%(27/34);对照组30例标本中未检测到Survivin蛋白表达、P-gp表达(P<0.01)。②39例骨肉瘤患者中发生转移的病例16例,其Survivin蛋白、P-gp表达水平显著高于未发生转移病例(P<0.05)。结论抑凋亡蛋白Survivin及多药耐药基因mdr1表达的P-gp的在骨肉瘤组织中呈现高表达,且两者表达水平与骨肉瘤病理分级和转移成正比。 Objective To investigate the expression of Survivin and P-glycoprotein (P-gp) in osteosarcoma and its relationship with the clinical and pathological features of osteosarcoma. Methods The expression of antiapoptotie protein Survivin and P-gp (expressed by multidrug resistance gene mdrl) were detected in 34 cases of osteosarcoma (the study group) and 30 cases of osteochondroma (the control group) using immunohistochemistry (SP method). The relationship between the expression of Survivin and P-gp, as well as its relevance to the clinical and pathological features of osteosarcoma was analyzed. Results (1) The positive expression of Survivin protein was found in 19 of the 34 cases of osteosarcoma, accounting for 55.9% (19/34), and the positive expression of P-gp was found in 27 cases (79.4%, 27/34). Specimens in the control group were found with no expression of Survivin and P-gp protein. (2) 16 cases in the study group were found with osteosarcoma metastasis, in which the expression of Survivin and P-gp protein was significantly higher than those patients without metastasis (P 〈0.05). Conclusion Survivin and P-gp show high expression in osteosarcoma, and the expression levels of the two proteins is positively related to tumor grade and metastasis of osteosarcoma.
出处 《海南医学》 CAS 2012年第6期1-3,共3页 Hainan Medical Journal
基金 深圳市科技局2011年科技计划项目(编号:201103117)
关键词 骨肉瘤 P-糖蛋白 SURVIVIN蛋白 Osteosarcoma P-glyeoprotein Survivin protein
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  • 1伍成奇,刘林嶓,李珊珊,陈言汤,牛扶幼,郝媛媛.病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达[J].郑州大学学报(医学版),2006,41(6):1038-1041. 被引量:1
  • 2马荣,陈曦海,张岂凡,朱镭,唐丽萍,王晶,成海燕,雷利娜.反义survivin核酸增强胃癌细胞对多西他赛敏感性及其逆转耐药机制的探讨[J].中华肿瘤杂志,2007,29(2):89-92. 被引量:11
  • 3Shin S,Sling B J,Cho Y S et al.An antiapoptotic protein human Survivin is a direct ichibitor of caspase-3 and-7.Biochemistry,2001,40:1117
  • 4Lu C D,Altieri D C,Tanigawa N.Expression of a novel antiapoptosis gene,Survivin,correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas.Cancer Res,1998,58:1808
  • 5Ambrosini G,Adida C,Altieri D C.A novel anti-apoptosis gene,Survivin,expressed in cancer and lymphoma.Nat Med,1997,3:917
  • 6Liston P,Roy N,Tamai K et al.Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.Nature,1996,379: 349
  • 7Trieb K,Lehner R,Stulnig T et al.Survivin expression in human osteosarcoma is a marker for survival.Eur J Surg Oncol,2003,29:379
  • 8Kuznetsova O M,Kushlinskii N E,Berezov T T.Vascular endothelial growth factor: its secretion in the bone tissue in the norm and in pathological states.Biomed Khim,2003,49:360
  • 9Kaya M,Wada T,Akatsuka T et al.Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis.Clin Cancer Res,2000,6:572
  • 10Mahotka C,Liebmann J,Wenzel M et al.Differential subcellular localization of functionally divergent survivin splice variants.Cell Death Differ,2002,9:1334

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