摘要
目的探讨中药肠毒清口服液对全身性炎性反应综合症(SIRS)的大鼠抗氧化能力、脾淋巴细胞增殖活性的影响,从而为中药肠毒清口服液治疗SIRS提供实验依据。方法将40只雄性SD大鼠随机分为5组(n=8)。用腹腔注射酵母多糖悬浊液造SIRS模型,对照组和实验组分别给予NS和不同浓度肠毒清口服液灌胃。末次给药后第3天处死,检测大鼠抗氧化能力、淋巴细胞增殖活性等。结果治疗组和模型组均出现一般情况的恶化;各组大鼠SI、T-AOC、MDA随着药物浓度的增加逐渐趋于NS组,但是无统计学意义(P>0.05);实验组总SOD与GSH-px明显低于NS组(P<0.05)。结论高剂量的肠毒清口服液可能通过增强机体免疫,缓解SIRS。
Objective To discuss the effect of Changduqing oral liquid on the anti-oxidative ability and proliferation of lymphocytes in model rats with systemic inflammatory response syndrome（SIRS） to provide experimental evidence for the treatment of SIRS.Methods 40 cases of healthy SD rats were randomly divided into five groups （8 cases for each group）.Intraperitoneal injection of zymosan was performed to construct the model rats with SIRS. Control group and different experimental groups were treated with NS or different doses of Changduqing oral liquid by gavage. Rats were executed at the 3rd day after the last time for treatment, and anti-oxidative ability and proliferation of lymphocytes were detected.Results General condition deterioration could be demonstrated in both therapy group and model group. SI, T-AOC and MDA were increased with the augment of drug concentration, but without significant difference, compared with NS group （P〉0.05）.SOD and GSH-px of rats in experimental group were significantly lower than those of rats in NS group（P〈0.05）.Conclusion High dose of Changduqing oral liquid could increase the immune function of rats to relief SIRS.
出处
《国际检验医学杂志》
CAS
2012年第3期327-328,344,共3页
International Journal of Laboratory Medicine
关键词
全身炎性反应综合征
淋巴细胞增殖活性
大鼠
肠毒清口服液
systemic inflammatory response syndrome activation lymphocytes Sprague-Dawley rats changduqing oral liquial
