摘要
目的 比较亮蓝（BBG）与吲哚菁绿（ICG）辅助内界膜（ILM）染色治疗特发性黄斑裂孔（IMH）的效果.方法 回顾性临床病例对照研究.对2009年1月至2010年6月在郑州大学第一附属医院眼科就诊44例（46只眼）IMH,随机分为两组：20只眼使用0.25％BBG染色（BBG组）；26只眼使用0.25％ICG染色（ICG组）.比较两组术中染色效果、剥膜率,术后两组患者的裂孔闭合率、最佳矫正视力（BCVA）（术后3月时）等改变.结果 两组患者的年龄、患病时间、术前BCVA差异均无统计学意义（P＞0.05）.术中BBG或ICG使所有患眼ILM染色,均有效增加了ILM的可见度,染色率为100％.BBG将ILM染成淡蓝色,ICG将ILM染成淡绿色,但后者染色效果更清晰.两组均顺利剥除ILM,剥除率为100％.分析两组间的裂孔闭合率（P=0.926）和BCVA提高程度（t=-0.359,P=0.721）差异均无统计学意义（P＞0.05）.两组BCVA与术前相比均显著提高（t=-25.947,-16.595,P值均=0.000）,差异具有统计学意义.两组病例均未发生严重手术并发症.结论 在特发性黄斑孔患者,0.25％BBG与0.25％ICG均使所有的ILM染色并剥离,染色率、剥膜率均为100％;两组术后裂孔闭合率、BCVA提高程度差异无统计学意义（P＞0.05）.
Objective To compare the effect between brilliant blue G and indocyanine green assisted internal limiting membrane （ILM） staining for idiopathic macular hole. Methods A retrospective study. Forty-four patients （46 eyes） with IMH （stage II or stage IV） were randomly divided into two groups. Group BBG （20 eyes） was underwent 0.25% BBG-assisted and Group ICG （26 eyes） was underwent 0.25% ICG-assisted ILM peeling. Main outcome measure was the chromaticity difference between the stained ILM, rate of anatomical hole closure, and best corrected visual acuity （BCVA）. Results There was no difference in ages of patients and BCVA between two groups before operation （P 〉0.05）. ILMs were stained well by BBG （100%） or ICG （100%） and the staining was sufficient to safely remove the ILMs in all cases （100%）. There was no difference in rate of macular hole closure （P =0.926）and visual improvement （t =-0.359, P =0.721） between two groups （P 〉 0.05）. The postoperative BCVA were significantly improved than the preoperative BCVA in both groups （t =-25.947, -16.595; P =0.000）. There were no serious complications in all patients. Conclusions The staining of ILM by both 0.25% BBG and 0.25% ICG is well enough to peel the ILMs safely in patients with IMH, though the former yields a less well-visibility.
出处
《中国实用眼科杂志》
CSCD
北大核心
2012年第2期116-119,共4页
Chinese Journal of Practical Ophthalmology
关键词
特发性黄斑裂孔
内界膜染色
亮蓝
吲哚菁绿
Idiopathic macular hole （IMH）
Internal limiting membrane peeling （ILMP）
Brilliant blue G （BBG）
Indocyanine green （ICG）
