摘要
目的系统评价存活蛋白(survivin)在肝细胞癌(hepatocellular carcinoma,HCC)中表达水平及与其临床病理特征的关系。方法计算机检索Cochrane Libtary(2011年第1期),PubMed、CNKI等数据库,并辅以手工检索,按照纳入与排除标准选择病例对照试验,评价质量及提取资料后采用Stata 11.0软件对数据库进行系统评价。结果共纳入14项研究,其中855例HCC患者,394例正常对照。Meta分析结果显示:Survivin在HCC组及正常对照组的表达差异有统计学意义[比值比(odds ratio,OR)=12.01,95%可信区间(confidence interval,CI)=6.39～22.58,P<0.05]。临床病理结果显示:Survivin在HCC患者男性组与女性组(OR=1.55,95%CI=0.97～2.46),年龄<60岁组与≥60岁组(OR=0.88,95%CI=0.46～1.69),HCC肿瘤直径<5cm组与≥5cm组(OR=1.07,95%CI=0.97～2.46),HCC甲胎蛋白(AFP)<400μg/L组与≥400μg/L组(OR=1.10,95%CI=0.61～1.98)的表达差异均无统计学意义(P>0.05)。Survivin在HCC低分化化组与中高分化组(OR=2.37,95%CI=1.07～5.26),临床分期Ⅲ+Ⅳ期与Ⅰ+Ⅱ期(OR=2.32,95%CI=1.41～3.83),局部或远处转移组与无局部或远处转移组(OR=2.47,95%CI=1.34～4.54)的表达差异均有统计学意义(P<0.05)。结论 Survivin在HCC中高表达,并且增加了其低分级、临床高分期及局部或远处转移的危险。
Objective To investigate relationship between survivin protein and clinic significance of hepatocellular carcinoma（HCC） with a meta analysis. Methods The published studies were searched in the Cochrane Library（Issue 1,2011）,Pubmed and CNKI databases,and other relevant journals were also hand searched to identify all the relevant case-control trials.Then,the qualities of the included trials were assessed and meta-analysis was performed by Stata 11.0 software. Results A total of 14 studies were recruited,HCC 855 patients,normal controls 394 subjects.As for the positive rate of survivin expression,significant differences were tested between pancreatic cancer vs normal tissues（OR=12.01,95%CI= 6.39-22.58）（P0.05）.No significant difference was tested between sex male vs female（OR=1.55,95%CI=0.97-2.46）（P0.05）,age 60 years vs ≥60 years（OR=0.88,95%CI=0.46-1.69）（P0.05）,tumor diameter 5 cm vs ≥5 cm（OR=1.07,95%CI=0.97-2.46）（P0.05）,and AFP concentration 400 μg/L vs ≥400 μg/L（OR=1.07,95%CI=0.97-2.46）（P0.05）.There were significant differences between histologic subtype low differentiation vs medium-high differentiation（OR=2.37,95%CI=1.07-5.26）（P0.05）,clinic stages Ⅲ-Ⅳ vs clinic stagesⅠ-Ⅱ（OR=2.32,95%CI=1.41-3.83）（P0.05）,local or distant metastasis vs non-local or distant metastasis（OR=2.47,95%CI=1.34-4.54）（P0.05）. Conclusion The abnormal expression of survivin suggested that survivin may play a role in histologic subtype,clinic stages and local or distant metastasis of HCC.
出处
《临床荟萃》
CAS
2012年第5期402-406,409,共6页
Clinical Focus
关键词
肝肿瘤
癌
肝细胞
存活蛋白
META分析
liver neoplasms
carcinoma, hepatocellular
survivin
Meta-analysis
