摘要
目的通过动物实验分析C/C-SiC复合材料与骨组织结合界面生长情况,初步判定C/C-SiC作为种植体修复材料的可行性。方法将24只日本大耳白兔,随机分为A、B、C 3组(每组8只),将实验材料(C/C-SiC)和对照材料(Ti),植入兔股骨内,A、B、C组对应取材时间为1个月、2个月、3个月,将带有种植体材料股骨标本脱钙、苏木素-尹红染色及扫描电镜观察两种种植体与骨组织结合界面生长情况。结果在术后1个月时,两种种植体材料与骨组织界面成骨细胞数和接触率无显著差异,在术后2个月时,实验材料与骨组织界面成骨细胞数和接触率均与对照材料有显著差异,实验材料与骨组织结合要滞后于对照材料,到术后3个月时,两种种植体材料与骨组织界面成骨细胞数和接触率均无显著差异,实验材料达到骨结合。结论 C/C-SiC复合材料植入兔股骨内术后3个月,种植体材料与骨组织能形成良好的骨结合。
Objective Animal study was designed to evaluate the interface between C/C-SiC composites and bone tissues,and to termine whether the C/C-SiC composites can be used as implant materials.Methods 24 white male rabbits were selected and randomly divided into A,B,C groups（n=8）.Experimental materials（C/C-SiC composites）and control materials（Ti）were implanted into rabbits femurs.The implantation time of A,B,C groups was 1,2,3months respectively.Femurs specimen which contained implant materials were decalcified and treated by decalcified,HE staining and SEM.Conjugation interfaces between implant materials and bone tissues were evaluated.Results Ratio of bone contact and the number of osteoblasts between C/C-SiC groups and Ti groups were not statistically different after 1 month＇s and 3 months implantation（P0.05）,but significantly different after 2 months′ implantation（P0.01）.Junctura ossium was realized between C/C-SiC composites and bone tisssue 3 months later.Conclusions C/C-SiC composites can achieve junctura ossium after 3 months′ of implantation,which has satisfactory biocompatibility.
出处
《口腔医学》
CAS
2012年第2期84-87,共4页
Stomatology
