摘要
目的探讨重度抑郁患者与正常对照者血浆催产素、皮质醇水平差异以及其与抑郁症状严重程度的关系。方法18～45岁重度抑郁患者20人，正常对照26人分别接受血浆催产素、皮质醇水平测量，病例组评定汉密顿抑郁量表。结果非参数检验显示抑郁患者血浆催产素水平高于正常对照组[（213．60±164．29）pg／ml，（112．27±101．21）pg／ml，z=-2．306，P=0．021]；差异具有统计学意义。血浆催产素对数值与抑郁严重程度成正相关（r=0．599，P=0．005）。病例组血浆皮质醇水平与正常对照组相比差异不具有统计学意义[（0．131±0．089）pg／ul，（0．107±0．077）pg/ul，z=-0．920，P=0．358]，但在抑郁患者中血浆皮质醇对数值与抑郁严重程度正相关（r=0．691，P=0．001）。催产素水平对数值与皮质醇对数值成正相关（r=0．743，P〈0．001）。多元线性回归模型分析显示重度抑郁患者中，催产素水平是影响抑郁严重程度的因素（校正R2=0．358，F=11．578，P=0．003）。结论与正常对照组相比，重度抑郁患者存在血浆催产素水平异常，血浆催产素水平可能是影响抑郁症状严重程度的因素，而皮质醇水平与抑郁严重程度的关系尚不能确定。
Objective To explore the difference of the oxytocin Levels and cortisol levels between major depression patients and normal controls, and the relationship of symptoms severity of major depression with oxytocin levels and cortisol levels. Methods Twenty 18 -45years old major depression patients and twenty six normal controls were tested by an enzyme-linked immunosorbent assay to evaluate the oxytocin levels and cortisol levels, and the Hamilton Rating Scale for Depression-IT item was used to evaluate the symptoms severity of depression in patient group. Results Mann-Whitney test showed there were significantly differences in oxytocin level between patients and controls （ （213.60 ± 164.29 ） pg/ml vs （ 112.27±101.21 ） pg/ml, z = - 2. 306, P = 0. 021 ）, but there were no significantly differences in cortisol level between two groups. Within the depressive sample（ （0. 131 ± 0. 089） vs （0. 107 ± 0. 077 ） pg/ul, z = - 0. 920, P = 0. 358 ）, the severity of depressive symptom was positive correlated to the value of oxytocin （ r = 0. 599, P = 0. 005 ） and cortisol（ r = 0. 691, P = 0. 001 ） , the value of oxytocin was also positive correlated to the value of cortisol（ r=0. 743, P〈0.01 ） ,Multiple liner regression analyses showed that the value of oxytocin is an impact factor of the severity of depression （ adjusted R2 = 0. 358, F = 11. 578, P = 0. 003 ）. Conclusion This study indicated that the value of plasma oxytocin maybe significantly differences between depression and normal controls and the plasma oxytocin level maybe a factor which influence the severity of major depression, the relationship of the cortisol value and the severity of depression can not be confirmed.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2012年第2期152-154,共3页
Chinese Journal of Behavioral Medicine and Brain Science
关键词
重度抑郁
催产素
皮质醇
Major depression
Oxytoein
Cortisol
