摘要
目前,外科治疗是非小细胞肺癌(non-small cell lung cancer,NSCLC)主要的治疗方法之一。手术治疗NSCLC的标准术式是切除原发病灶和清扫肺门及纵隔淋巴结。尽管如此,早期肺癌患者术后的复发率仍然很高。其原因主要为两个方面,一是清扫淋巴结不彻底;二是淋巴结微转移(micrometastasis,MM)。纳米炭混悬液的出现为我们解决上述问题提供了一种新的思路。纳米炭混悬液是一种淋巴示踪剂,其主要作用是淋巴示踪和靶向化疗。淋巴示踪使术中对淋巴结的清扫更彻底、更完全;靶向化疗可以将术中残留的肿瘤细胞进一步清除,以防止术后肿瘤复发。在胃肠道肿瘤和乳腺肿瘤的外科治疗中,纳米炭混悬液已得到较广泛的应用,作用和疗效肯定;而纳米炭混悬液在肺癌患者外科治疗中的应用是一种尝试,它可在术中给胸外科医生提供一定的帮助,使肺癌患者获得更好的预后。现对纳米炭混悬液的特点、应用方法、在NSCLC外科治疗中的临床应用进行综述。
Surgery is an effective therapy for non-small cell lung cancer（NSCLC）.The standard operation includes lobectomy and systematic dissection of lymph nodes.However,postoperative tumor recurrence is common even among incipient patients due to incomplete dissection of lymph nodes and micrometastasis of lymph nodes.Injecting a carbon nanoparticles suspension is a new technique aimed at preventing this recurrence.The carbon nanoparticles carry lymph node tracers that help surgeons locate lymph nodes in order to clean them thoroughly.The tracers also target the lymph nodes for chemotherapy,thus killing residual tumor cells intraoperatively to avoid postoperative cancer recurrence.Carbon nanoparticles suspension injection is already widely and successfully used in surgery for gastrointestinal and mammary gland tumors,and is being tested for effectiveness in NSCLC patients.Some studies have indicated that carbon nanoparticles suspension injection is effective in NSCLC patients and improves their prognoses.We reviewed the features,application methods,and clinical applications of studies of carbon nanoparticles suspension injection for NSCLC.
出处
《中国胸心血管外科临床杂志》
CAS
2012年第1期73-76,共4页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
非小细胞肺癌
手术
纳米炭混悬液
淋巴示踪
靶向化疗
Non-small cell lung cancer
Surgery
Carbon nanoparticles suspension
Lymph node tracing
Targeted chemotherapy
