摘要
目的分析中国老年汉族人群中血小板膜糖蛋白(GP)Ⅲa(Leu33 Pro)基因血小板抗原(PLA)的T/C多态性与阿司匹林抵抗(AR)的关系。方法选择长期服用阿司匹林患者共432例,分为AR组250例,阿司匹林敏感组(AS组)182例,检测花生四烯酸(AA)诱导的血小板聚集率,DNA测定GPⅢa基因(Leu33Pro)PLA(T/C)多态性。结果 AR组PLA1/A1基因型240例,PLA1/A2基因型10例;AS组均为PLA1/A1基因型。PLA2基因型在AR组中的发生率为4.0%,在总人群中的发生率为2.3%,差异有统计学意义(P<0.05)。结论中国老年汉族人群中,AR患者的PLA1/A2基因型表达高于AS患者,考虑PLA1/A2基因型与中国老年汉族人发生AR有关。
Objective To study the relation between glycoprotein Ⅲ a [GPⅢ a （Leu33Pro）] T/C polymorphisms and aspirin resistance（AR）in aged Chinese. Methods Four hundred and thirtytwo aged Chinese undergoing chronic aspirin therapy were divided into AR group（n：250） and aspirin sensitive（AS） group （n = 182）. Arachnoid acid induced platelet aggregation and GPⅢ a （Leu33Pro）T/C polymorphisms were detected with DNA. Results The PLA1/A1 and PLA1/A2 genotype heterozygotes were detected in 240 and 10 subjects, respectively. The PLA1/A1 genotype hornozygotes were only detected in AS group. The prevalence of PLA2 genotype was 4.0% and 2.3% in the AR group and in the total population,respectively（P〈0.05）. Conclusion The prevalence of PLA1/A2 genotype is higher in AR group than in AS group,which is related with AR in aged Chinese.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2012年第3期287-289,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
