期刊文献+

四项指标联合检测在细菌性感染疾病中的诊断意义 被引量:15

The diagnostic significance of the joint detection of 4 indicators in bacterial infective disease
下载PDF
导出
摘要 目的探讨细菌性感染疾病患者血清超敏C反应蛋白(hs-CRP)、白细胞、中性粒细胞分类及中性粒细胞碱性磷酸酶(NAP)变化的相关性。方法采用免疫比浊法测定hs-CRP、血细胞分析仪法测定白细胞及中性粒细胞分类、偶氮偶联法检测NAP;选取133例细菌性感染疾病患者作为感染组,60名健康体检者作为对照组。结果感染组hs-CRP、白细胞、中性粒细胞分类、NAP及NAP积分均高于对照组(P<0.01)。感染组CRP水平升高有130例,白细胞升高有118例,NAP升高有126例,中性粒细胞分类升高有116例,hs-CRP+白细胞+中性粒细胞分类+NAP积分4项指标联合检测有131例升高。结论血清hs-CRP、白细胞、中性粒细胞分类及NAP检测是感染性疾病早期鉴别诊断快速有效的诊断指标之一,CRP及NAP浓度的监测对细菌性感染的早期诊断,比白细胞计数更敏感,联合检测有利于提高诊断率。 Objective To explore the pertinence of the joint detection of serum high sensitivity C-reactive protein (hs-CRP), white blood cell (WBC), neutropenia (NC) classification and neutrophil alkaline phosphatase (NAP) in patients who were infected by bacteria. Methods Immune turbidimetrie method was used to determine the level of hs- CRP. Blood cell analyzer was applied to determine the WBC and NC classification. AZO coupling method was used to detect of NAP; 133 patients with bacterial infections as infection group, 60 cases of healthy people as control group. Results Infection group hs-CRP, WBC, NC, NAP and NAP integral classification were higher than that of control group (P〈O.01). Infection group CRP concentration was elevated in 130 patients, high levels of white blood cells in 118 cases, NAP 126 cases of NC classification of elevated, elevated in 116 eases, hs-CRP+WBC+NC+NAP integral classification of 4 indexes of combined detection of 131 cases of elevated. Conclusion The serum hs-CRP, WBC, NC classification and NAP detection is infectious disease early differential diagnosis and fast and effective diagnosis index. CRP and NAP concentration monitoring in early diagnosis of bacterial infection is more sensitive than WBC count and helpful to improve the diagnosis rate of combined detection.
出处 《实用医技杂志》 2012年第3期238-240,共3页 Journal of Practical Medical Techniques
关键词 C反应蛋白质 白细胞计数 中性粒细胞分类 中性粒细胞碱性磷酸酶 细菌感染 C-reactive protein Leukocyte count Neutrophil classification Neutrophil alkaline phosphatase Bacterial infections
  • 相关文献

参考文献7

二级参考文献33

  • 1叶成林,张伟民,门琼,吴瑾瑜,施媛,冯菲.CRP、NAP、WBC、DC的联合检测在中晚期肿瘤患者细菌感染中的诊断价值[J].河南肿瘤学杂志,2005,18(3):202-203. 被引量:13
  • 2陈珍严,李呐,刘靖,邱飞英.不同剂量的阿托伐他汀对不稳定心绞痛患者冠脉炎症的影响[J].中国心血管病研究,2005,3(7):520-523. 被引量:5
  • 3白雪梅,杨平,王莹,陈同辛.外周血中性粒细胞百分率在小儿急性上呼吸道感染中的应用[J].临床儿科杂志,2005,23(9):664-666. 被引量:21
  • 4Hojo Y, Ikeda U, Takahashi M, et al. Matrix metalloproteinase-1 expression by interaction between monocytes and vascular endothelial cells [J].J Mol Cell Cardiol, 2000, 32(8): 1 459-1 468.
  • 5Du-Clos TW, Mold C. C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity [J]. Immunol Res, 2004, 30(3): 261-277.
  • 6Sjowall C, Wettero J. Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins [J]. Clin Chim Acta, 2007, 378(1-2) : 13-23.
  • 7Marnell L, Mold C, Du-Clos TW. C-reactive protein: ligands, receptors and role in inflammation [J]. Clin Immunol, 2005, 117 (2) : 104-111.
  • 8Williams RC Jr, Harmon ME, Burlingame R, et al. Studies of serum C-reactive protein in systemic lupus erythematosus [J]. J Rheumatol, 2005, 32(3): 454-461.
  • 9Agrawal A, Shrive AK, Greenhough TJ, et al. Topology and structure of the C1q-binding site on C-reactive protein [J]. J Immunol, 2001, 166(6): 3 998-4 004.
  • 10Baek JE, Chang JW, Min WK, et al. Serum high-sensitivity C- reactive protein is not increased in patients with IgA nephropathy [J]. Nephron Clin Pract, 2008, 108(1): c35-c40.

共引文献78

同被引文献88

引证文献15

二级引证文献106

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部