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HPLC法测定兰索拉唑肠溶片的血药浓度 被引量:3

HPLC method for the determination of lansoprazole enteric-coated tablets in human phasma
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摘要 目的建立HPLC法测定兰索拉唑肠溶片的血药浓度。方法采用高效液相色谱法,色谱柱:Hypersil ODS(250 mm×4.6 mm,5μm),柱温:40℃,流动相为水∶乙腈∶正辛胺(620∶380∶1),流速:1.2 ml.min-1,检测波长:285 nm。结果兰索拉唑在0.05~2.00 mg.L-1范围内线性关系良好(r=0.999 8),平均回收率为99.48%,RSD=4.50%。结论该方法灵敏、准确、稳定,适用于兰索拉唑的血药浓度检测。 Objective To develop an HPLC method for the determination of plasma concentrations of Lansoprazole enteric-coated tablets.Methods HPLC was adopted.Hypersil ODS(250 mm×4.6 mm 5 μm) was used,with column temperature at 40℃.The mobile phase was water∶ acetonitrile∶ n-octyl amine(620∶ 380∶ 1 v/v).The flow rate was 1.2 ml·min-1 and detection wavelength was 285 nm.Results Within the range between 0.05 and 2.00 mg·L-1,there was a good linear relationship(r=0.999 8).The average recovery was 99.48%,and RSD was 4.50%.Conclusion The method is simple,accurate,stable and can be applied to determine plasma concentrations of lansoprazole enteric-coated tablets.
作者 杨言言
出处 《安徽医药》 CAS 2012年第2期180-181,共2页 Anhui Medical and Pharmaceutical Journal
关键词 高效液相色谱法 兰索拉唑肠溶片 血药浓度 HPLC lansoprazole enteric-coated tablets plasma concentrations
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