摘要
为观察不同剂量阿苯达唑对感染曼氏裂头蚴小鼠的疗效,将72只小鼠随机均分为A~H等8组,每鼠经口感染5条裂头蚴。感染后1周,A~C组小鼠应用阿苯达唑灌胃治疗1个疗程(2次/d×7d),阿苯达唑1个疗程的总剂量分别为1700、2500和3300mg/kg,治疗后1周剖杀;E~G组小鼠治疗1个疗程后间隔7d,再治疗1个疗程,总剂量同A~C组,第2疗程结束后1周剖杀;D、H组小鼠仅灌服蒸馏水,分别作为A~C组和E~G组小鼠的对照组。检获裂头蚴,计算各组小鼠的平均虫数和减虫率。结果发现,A~C组小鼠的减虫率分别为20.0%、20.0%和24.9%,差异无统计学意义(x2=0.351,P〉0.05)。E~G组小鼠的减虫率分别为22-3%、36.4%和31.9%,差异亦无统计学意义(x2=1.812,P〉0.05);应用相同阿苯达唑剂量治疗1个与2个疗程后,小鼠减虫率的差异均无统计学意义(P〉0.05)。表明阿苯达唑对裂头蚴感染小鼠无明显的治疗效果。
In order to observe the efficacy of albendazole for the treatment of mice infected with Sparganum mansoni, a total of 72 mice were divided into 8 groups (9 mice each), each mouse was orally infected with 5 plerocercoid. At one week after infection, groups A--C were treated with a 7-day course of albendazole (1700, 2500, and 3 300mg/kg, twice daily), and sacrificed at 1 week post-treatment; groups E-G were treated with the second course of albendazole with the same dosage at 1 week interval after the first course, and sacrificed at 1 week after the second course; the groups D and H were used as control for A-C and E-G, respectively. After the infected mice were sacrificed, the mean number of worms recovered was observed and worm reduction rate was determined. When treating with one course of albendazole at 1 week post infection, the worm reduction rate in groups A-C was 20.0%, 20.0% and 24.9%, respectively (x2=0351, P〉0.05). After treatment with two courses of albendazole, the worm reduction rate in groups E-G was 223%, 36.4% and 31.9% (X2=L812, P〉0.05). The difference of the worm reduction rate in the infected mice treated with 1 and 2 courses of albendazole showed no statistical significance (P〉0.05). The results indicated albendazole has no obvious efficacy for treating sparganosis in mice.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2012年第1期71-72,共2页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家自然科学基金(No.30972579)
河南省医学科技攻关(No.201003006)
郑州大学创新实验计划(No.2011-242)~~