摘要
目的:了解52例中枢神经系统感染患儿甲状腺功能情况,分析甲状腺功能异常与病情危重度和昏迷之间的关系,以提供临床参考。方法:用化学发光法检测甲状腺功能,并用Glasgow昏迷评分和APACHE行危重病评分评估治疗1周前后的病情。结果:52例患者有22例出现甲状腺功能改变,异常组中,FT3异常者所占比例为73.9%,FT4异常占43.5%,其均值比正常组明显下降,P<0.05。FT3、FT4、TSH均下降者预后较差。甲状腺功能异常组患者昏迷时间比正常组时间长(P<0.05),病情重(P<0.05),预后差。结论:中枢神经系统感染患者应尽早评估甲状腺功能以判断病情,协助评估病情和诊疗。
Objective： To investigate the relation between the coma or APACHEⅡ degree and thyroid function in children with central nervous system（CNS） infection.Methods： Clinical data of 52 patients with CNS infection were analyzed.Free triiodothyronine（FT3）,triiodothyronine（T3）,free thyroxin（FT4）,thyroxine（T4）,and thyroidstimulati hormone（TSH） were assayed,and the APACHE degree and Glasgow Coma Scale were determined in one week after admitted in ICU.They were divided into two groups by thyroid function,one was normal,the other was abnormal.Results： In In the abnormal thyroid function cases,there were 73.9% low FT3 and 43.5% low FT4.Compared those in the normal thyroid function cases,the time of coma was longer and one week Glasgow Coma Scale and APACHE degree were lower（P0.05）.Conclusion： It is important to evaluate the thyroid function as soon as possible for the CNS infection patients.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2012年第2期266-268,共3页
Medical Journal of Wuhan University
