摘要
目的评价地塞米松治疗剖宫产术病人脊椎．硬膜外联合麻醉穿刺时神经根损伤的效果。方法择期脊椎-硬膜外联合麻醉下行剖宫产术在穿刺过程中发生神经根损伤的病人93例，年龄21～36岁，采用随机数字表法，将其随机分为3组（n=31）。发生神经根损伤后即刻、术毕及术后5min时硬膜外注射地塞米松，D1组剂量为1、2、2mg，D2组剂量为2、4、4mg，C组分别给予等容量生理盐水2、4、4ml。于术后14d评价治疗效果。结果与c组比较，D1组和D2组治疗效果较好（P〈0．01），D，组和D1组间治疗效果差异无统计学意义（P〉0．05）。结论硬膜外注射地塞米松5mg治疗脊椎-硬膜外联合麻醉穿刺时神经根损伤的效果较好。
Objective To evaluate the effects of epidural dexamethasome on nerve root injury caused by epidural puncture during performance of combined spinal-epidural anesthesia for cesarean section. Methods Nerve roots were injured during performance of combined spinal-epidural anesthesia in 93 parturients aged 21-36 yr scheduled for cesarean section. The patients were randomly divided into 3 groups （ n = 31 each） ： group control （group C）; group low-dose dexamethasone （group D1 ） and group high-dose dexamethasone （group D： ）. Dexamethasone 5 mg and 10 mg were divided into 3 parts （1, 2, 2 mg and 2, 4, 4 mg） and injected into the epidural space at 3 time points-immediately after nerve roots were punctured, at the end of operation and 5 min after operation, in groups DI and D2 respectively. The results of the treatment with dexamethasone were evaluated at 14 d after operation. Results The results of treatment with dexamethasone were significantly better in groups D1 and D2 than in group C, but there was no significant difference between groups D1 and D2 . Conclusion Epidural dexamethasone 5 mg can ameliorate the nerve root injury produced by epidural puncture.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2011年第12期1437-1439,共3页
Chinese Journal of Anesthesiology
关键词
地塞米松
注射
硬膜外
注射
脊髓
脊神经根
手术中并发症
剖宫产术
Dexamethasone
Injections, epidural
Injections, spinal
Spinal nerve roots
Intrao- perative complications
Cesarean section
