摘要
以7-氨基头孢烷酸为模板分子,4-乙烯基吡啶为功能单体,乙二醇二甲基丙烯酸酯为交联剂,制备了7-氨基头孢烷酸分子印迹聚合物。以该分子印迹聚合物为固相萃取材料,以高效毛细管电泳为检测手段,进行头孢氨苄、头孢拉定、头孢哌酮、头孢唑啉等4种头孢类药物的色谱分析。结果表明,该方法能有效萃取和检测鸡肉中的药物。在试验条件下,4种头孢类药物的回收率为78.00%～83.04%,RSD为2.18%～3.79%。
A fast and accurate method for detecting cephalosporin drugs residues in chicken muscles was established.7-aminocephalosporanic acid molecular imprinted polymers（7-ACA MIP）was synthesized using 7-ACA as template molecules,4-vinylpyridine as functional monomer and ethylene glycol dimethacrylate as cross-linking agent.Cephalosporin drugs（cefalexin,cefradine,cefoperazone and cefazdin） residues in chicken muscles was determined by molecular imprinted solid phase extraction-high performance capillary electrophoresis（MISPE-HPCE）,using 7-ACA MIP as solid phase extraction materials.The recoveries of four drugs at different levels were in the range of 78.00%-83.04%,and the relative standard deviations（RSD） were in the range of 2.18%-3.79%.It indicated that MISPE-HPCE method may be suitable for analysis of cephalosporin drugs residues in chicken muscles.
出处
《江苏农业学报》
CSCD
北大核心
2012年第1期193-197,共5页
Jiangsu Journal of Agricultural Sciences
基金
国家十一五科技支撑计划子项目(2006BAK02A08-4)
关键词
分子印迹固相萃取
高效毛细管电泳
7-氨基头孢烷酸
头孢类药物
鸡肉
molecular imprinted solid phase extraction
high performance capillary electrophoresis
7-aminocephalosporanic acid
cephalosporin drug
chicken muscle
