摘要
目的探讨大肠癌患者血浆D-二聚体的变化与疗效的关系。方法检测60例进展期大肠癌患者术前及术后2年的血浆D-二聚体浓度。结果术前进展期大肠癌缓解组血浆D-二聚体低于转移组(P<0.01),治疗后缓解组血浆D-二聚体低于术前(P<0.01),转移组血浆D-二聚体高于术前(P<0.01)。结论进展期大肠癌患者血液处于高凝状态。恶性程度高、侵袭性强、对手术化疗反应差的肿瘤患者在治疗前后均有较高的D-二聚体水平。
Objective To explore relationship of plasma D-dimer with therapeutic effect in patients with colorectal cancer.Methods Plasma D-dimer were detected before and after 2 years treatment in 60 patients with advanced colorectal cancer.Results Plasma D-dimer level of remission in preoperative advanced colorectal cancer group was lower than the transfer group(P<0.01).Plasma D-dimer level in remission after treatment of plasma D-dimer group was significantly decreased after surgery(P<0.01),plasma D-dimer level of transfer group after operation was higher than preoperative time(P<0.01).Conclusion The blood of patients with advanced colorectal cancer is in hypercoagulation state.Levels of D-dimer in patients with highly malignant,invasive strongly and poor response to chemotherapy are higher before or after treatment.
出处
《检验医学与临床》
CAS
2012年第5期517-517,520,共2页
Laboratory Medicine and Clinic
基金
重庆市长寿区科委科研项目
关键词
D-二聚体
大肠癌
化疗
D-dimer colorectal cancer clinical efficacy
