摘要
目的:探讨直肠超声引导125碘粒子植入治疗前列腺癌的临床疗效及并发症分析。方法:回顾性分析我院2009年2月～2011年2月62例患者,随机分为两组,对照组采用全雄激素阻断(双侧睾丸切除+抗雄激素药物)治疗,观察组采用直肠超声引导下125碘粒子植入术治疗,比较两组治疗前后的PSA值变化、并发症发生率及5年生存率。结果:术后2个月,两组患者前列特异性抗原值均有明显下降,但两组相比无统计学意义(P>0.05);术后6个月,观察组患者前列特异性抗原明显低于观察组,两组相比有统计学意义(P<0.05)。术后对照组患者并发症的发生率为83.3%,观察组患者并发症的发生率为34.4%,两组相比有统计学意义(P<0.05)。结论:经直肠超声引导下125碘粒子植入是治疗前列腺癌有效方法,疗效确切,创伤小、定位准确、并发症少,值得临床推广。
To investigate the clinical efficacy and complication of implanted 125 iodine guided by transrectal ultrasound for prostate cancer. Methods：A total of 62 patients admitted from February 2009 and February 2011 were randomly divided into two groups. Patients in control group were treated by maximal androgen blockade therapy（bilateral testectomy antiandrogen drug）. While patients in study group were treated with transrectal ultrasoundguided 125 iodine particle implantation treatment. PSA val- ue, complication incidence and 5year survival rate were observed and compared. Results： After two months, prostate specific antigen value were decreased obviously, but without statistically significant difference between two groups （P〈0.05） i After six months , prostate specific antigen value was significantly lower in control group than the experimental group （P〈0.05）. Postoperative complications incidence was 83.3% in control group, and 34.4% in experimental group, with significant difference between two groups（P%0.05）. Oonclusion.. 125 iodine implantation guided by transrectal ultrasound is effective treatment for prostate cancer, with small trauma, accurate positioning and less complications. It is worthyclinical application
出处
《海南医学院学报》
CAS
2012年第3期368-369,372,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(11221079)~~
关键词
前列腺癌
全雄激素阻断
125碘粒子
Prostate cancer
Maximal androgen blockade
125 iodine particle
