摘要
目的为评价改水降氟对地方性氟中毒的防治效果。方法检测分析了（未改水）病区组、改水病区 组、非病区组 ８～１２岁儿童的尿氟和氟毒性效应指标。结果尿氟均值病区组明显高于改水病区组（ Ｐ <０．０１ ） 和非病区组（Ｐ<０．０１）；尿羟脯氨酸（ＨＯＰ）排泄量均值病区组亦明显高于改水病区组（Ｐ<０．０１）和非病区组（ Ｐ＜０．０１）；改水病区组８～１２岁儿童氟斑牙患病率由卫０年前的８２．４％降至６.４５％，明显低于病区组（Ｐ＜ ０.０１）、斑釉齿指数呈依次递减趋势，病区组，改水病区组、非病区组分别为０．７３，０．０３，０，０２６。血清肌酸磷酸激酶 （ＣＰＫ）活性均值病区组非常明显地高于改水病区组（ Ｐ<０．０１）和非病区组（ Ｐ < ０． ０１）。上述各指标改水病区 组与非病区组比较，均无显著性差异（ Ｐ ＞ ０． ０５）。结论改水降氟后，人群饮用水中摄氟量下降，致使体内氟负 荷减轻，氟毒性效应指标改善，起到了明显的防护作用。
Objective Assess the effects of defluoride of drinking water. Methods The urine fluorine and indices of fluoride toxic effect were determined for three groups of children which were 8-12 years old. The three groups were nondefluoride group,defluoride group and non-epidemic area group. Results The mean of urine fluorine of non-defluoride group was much higher than that of defluoride group (P <0. 01 ) and non-epi- demic area group(P < 0. 01 ).The mean of urine hydroxyproline (HOP) was much higher than that of defluoride group (P < 0. 01 ) and non-epidemic area group (P < 0. 01 ). After ten years of defluoride of drinking water,the rate of dental fluorosis dropped from 82.4% to 6. 45 %. The rate (6. 45 % ) was much lower than that of non- defluoride group(P < 0. 01 ). The dental fluorosis indices of non-defluoride group,defluoride group and non- epidemic area group were decrasing progressively,namely 0.73, 0.03, 0.026. In the non-defluoride group the mean of activity of urine creatine phosphokinase (CPK) was much higher than that in defluoride group (P<0. 01 ) and non-epidemic area group (P <0. 01 ). Between the defluoride group and non epidemic area group, the indices mentioned above have no significant difference (P > 0. 05 ). Conclusions After defluoride of drinking wafer,the body fluorid load came down and indices of fluoride toxic effect were improved,because of the decresing of expo- sure levels to fluorine.
出处
《中国地方病学杂志》
CAS
CSCD
2000年第2期110-112,共3页
Chinese Jouranl of Endemiology
关键词
改水降氟
氟中毒
儿童
地方性
Defluoride of drinking water
Urin fluorine
Hydroxyproline
Dental fluorosis
CPK
