摘要
观察粒细胞集落刺激因子 ( G- CSF)对联合化疗的 5 5例肺癌患者的骨髓保护作用。其中小细胞肺癌 15例 ,非小细胞肺癌 40例。分为三组 :A组未用 G- CSF,B组在出现 °或 °度骨髓抑制时使用 G- CSF,C组于化疗结束后 48h使用。结果为 A组多数患者推迟化疗 ,A、 B两组细菌感染率均高于 C组。提示 G- CSF在肺癌化疗中具有骨髓保护作用 ,能减少感染发生 ,并确保化疗如期进行。化疗后 48h使用 G- CSF效果更佳。
Marrow protective effect of G CSF in 55 patients with lung cancer under combined chemotherapy was observed The patients were divided into three groups In group A,no G CSF was given G CSF was applied to group B patients when grade Ⅲ or Ⅳ marrow suppression was encountered G CSF was used in group C patients 48h after combined chemotherapy The results show that chemotherapy in most group A patients was delayed and infection rate was higher in group A and B These fidings indicate that G CSF have marrow protective potential for lung cancer patients under chemotherapy and the best time to use G CSF be 48h after chemotherapy
出处
《山东医药》
CAS
北大核心
2000年第4期16-17,共2页
Shandong Medical Journal
关键词
肺肿瘤
药物疗法
G-CSF
骨髓抑制
G CSF Lung cancer Combined chemotherapy Bone marrow suppression
