摘要
目的探讨肾病综合征患者血清β2微球蛋白水平与凝血及纤溶指标间的关系。方法收集108例明确诊断为肾病综合征的患者,同时收集30例健康人群作为对照组,入院后采集空腹静脉血用于血清白蛋白、总胆固醇、β2微球蛋白、D-二聚体、抗凝血酶-III、活化部分凝血活酶时间、凝血酶原时间、肌酐和尿素氮检测;采用Pearson相关分析血清β2微球蛋白水平与D-二聚体、抗凝血酶-III、活化部分凝血活酶时间和凝血酶原时间的关系。结果肾病综合征患者血清白蛋白、β2微球蛋白和抗凝血酶-III均低于健康对照组,而血清总胆固醇和D-二聚体水平高于对照组,且活化部分凝血活酶时间和凝血酶原时间长于对照组,差异均有统计学意义(P<0.05);Pearson相关分析结果提示血清β2微球蛋白水平与患者血浆D-二聚体水平、活化部分凝血活酶时间及凝血酶原时间呈负相关,与抗凝血酶-III呈正相关。结论血清β2微球蛋白水平不但能够早期反映肾病综合征患者的肾功能水平,同时还能够反映患者凝血及纤溶情况,因此,检测肾病综合征患者血清β2微球蛋白水平可能能够预测患者的出血及血栓风险。
Objective To explore the relationship between serum level of β2-microglobulin（β2-MG） and indicators of coagulation and fibrinolysis in patients with nephrotic syndrome（NS）.Methods One hundred and eight patients diagnosed as NS（NS group）and 30 healthy persons as control group were enrolled in this study.Fasting blood samples were drawn for determining serum levels of albumin（ALB）,total cholesterol（TC）,β2-MG,D-dimer（DD）and antithrombin-III（AT-III）,activated partial thromboplastin time（APTT）,prothrombin time（PT）,creatinine（Cr） and blood urea nitrogen（BUN）.The relationship between serum level of β2-MG and DD,AT-III,APTT and PT were analyzed by Pearson correlation analysis.Results（1） In comparison with control group,serum levels of ALB,β2-MG and AT-III in NS group were lowered,levels of TC and DD were higher,and APTT and PT were longer,and the difference between these two groups was significant（P0.05）.（2） serum level of β2-MG was negative correlation with DD,APTT and PT,while positive correlation with AT-III in patients with NS.Conclusion Serum level of β2-MG can not only be used as an early indicator of renal function but it also can be used as an indicator of coagulation and fibrinolysis,thus detection of serum level of β2-MG can predict the risk of bleeding and thrombosis in patients with NS.
出处
《临床和实验医学杂志》
2012年第6期417-419,共3页
Journal of Clinical and Experimental Medicine
关键词
肾病综合征
Β2微球蛋白
凝血功能
Nephrotic syndrome
β2-Microglobulin
Coagulation function
