摘要
目的观察快速输注羟乙基淀粉130/0.4联合小剂量麻黄碱预防剖宫产术腰硬联合麻醉低血压的效果以及恶心、呕吐的发生率。方法选择足月妊娠产妇90例,随机分为3组,每组30例。A组:单纯乳酸钠林格氏液组;B组:羟乙基淀粉氯化钠注射液组;C组:羟乙基淀粉氯化钠注射液联合麻黄碱组。观察3组麻醉开始前10 min,麻醉后5 min、10 min1、5 min、手术结束血压、心率的变化及恶心呕吐的发生情况。结果 C组麻醉前后血压、心率变化小,麻醉后各时点,与A组和B组比较差异有显著性(P<0.01或0.05),恶心呕吐的发生率也明显少于A,B组(P<0.01)。B组血压下降程度及低血压发生率虽然少于A组,但组间比较差异无显著性(P>0.05)。结论羟乙基淀粉130/0.4联合小剂量麻黄碱能较好的预防剖宫产腰硬联合麻醉低血压的发生及减少恶心呕吐的发生率。
Objective To observe the effects of fast infusing hydroxyethyl starch（HES）130/0.4 combined with low dose ephedrine to prevent hypotension,nausea and vomiting during combined spinal-epidural anesthesia（CSEA） in caesarean section.Methods 90 parturients of CSEA were randomly assigned into three groups with 30 cases each.The patients in group A were only infused with sodium lactate Ringer＇s solution during caesarean section while those in group B only with HES130/0.4.The patients in group C were infused with HES130/0.4 combined with low dose ephedrine during caesarean section.Blood pressure（BP）,heart rate（HR） and side effects were recorded and compared among the three groups 10 min before anesthesia（T0）,5 min（T1）,10 min（T2）,15 min（T3） after anesthesia and after operation（T4）.Results In group C,BP and HR were no markedly changed at all time points（P0.05）.In groups A and B,BP decreased and was significantly lower than that in group C（P0.01,P0.05） in time points after anesthesia,especially in group A at T1 and T2.HR increased and was significantly higher than that in group C（P0.05）.There was no significant difference between group A and group B.Incidence of nausea and vomiting in group C was significantly lower than in group A and group B（P0.01）.Conclusion Infusing HES130/0.4 combined with low dose ephedrine can prevent hypotension,nausea and vomiting during CSEA in caesarean section.
出处
《淮海医药》
CAS
2012年第2期117-118,共2页
Journal of Huaihai Medicine
