摘要
给Wistar大鼠饮用含NaF(100m g/L)的蒸馏水90天,同时灌胃给予Na2SeO3 [0.1m g/(kgBW·d)]和/或ZnSO4[14.8 m g/(kgBW·d)]。生化、病理和超微病理检测结果表明氟可导致肾脏严重受损。其主要毒作用部位为肾近曲小管,脂质过氧化作用是氟肾毒性的机理之一。一定剂量的硒、锌可通过拮抗氟诱导的脂质过氧化作用拮抗氟致肾脏损伤,硒。
Wistar rats were provided with distilled water containing NaF(100 mg/L),and were administered through gavage with Na 2SeO 3 [0 1mg/(kgBW·d)] and/or ZnSO 4[14 8 mg/(kg BW·d)]. The results of biochemical, pathological and ultrastructural examinations showed that fluoride could cause serious renal impairments. The major damage induced by fluoride was epithelia of proximal renal tubules. The lipid peroxidation might be one of the mechanisms of fluoride toxicity. Na 2SeO 3 and ZnSO 4 could antagonize the renal impairments induced by fluoride through their antioxidation. The cooperative effect of Na 2SeO 3 and ZnSO 4 was more powerful than either Na 2SeO 3 or ZnSO 4 alone.
出处
《卫生研究》
CAS
CSCD
北大核心
2000年第1期21-23,共3页
Journal of Hygiene Research
基金
"九五"国家医学科技攻关项目!(No.96-906-04-02)
关键词
氟
硒
锌
拮抗作用
肾损伤
fluoride,selenium,zinc,antagonism,renal impairments
