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外环境中脊髓灰质炎病毒监测研究 被引量:4

Monitoring on Poliovirus in Environment
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摘要 [目的] 为监测外环境中是否还有脊髓灰质炎 (Polio) 野病毒株循环。[方法] 在曾是Polio 流行区的地区, 于1997~1998年定点采集0~4岁儿童粪便538 人份, 河塘水88份, 市自来水厂源水8份和出厂水6份。[结果] 从粪便和水中分离到PVⅠ型28株、PVⅡ型1株、PVⅢ型5 株、NPEV42株。分离的PV温度特征试验, 判为弱毒(疫苗) 株; RT-PCR型内分析亦为疫苗(Sabin) 相关株。[结论] 在具有对Polio高免疫屏障的人群和外环境中, 仍有Polio 病毒循环, 但均为疫苗相关株。 Objective]To find out the circulation of wild strains of poliovirus [Methods]538 fecal specimens were sampled from 0~4 year old healthy children,88 samples from river and pool water,8 samples from source water and 6 treated water samples of water plants were sampled and analyzed in areas which were polio epidemic area before during 1997~1998 [Results]28 strains of type Ⅰ poliovirus,1 strain of type Ⅱ poliovirus,5 strains of type Ⅲ poliovirus and 42 strains of NE poliovirus were isolated from fecal specimens and water samples,which were identified to be vaccine related strains(low toxicity) by sensitive test of temperature and RT PCR intratypic analysis [Conclusion]The circulation of vaccine related strains of poliovirus still existed among population with high immune barrier to poliovirus and in environment
出处 《环境与健康杂志》 CAS CSCD 北大核心 2000年第1期21-23,共3页 Journal of Environment and Health
基金 连云港市科学基金!资助项目(SH97008)
关键词 脊髓灰质炎病毒 疫苗相关性 野病毒性 环境监测 Environment Poliovirus Vaccine related strains Wild virus strain
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共引文献30

同被引文献21

  • 1王华庆,陈丽娟,郭欣,张合润,王玉梅,罗明,贺雄,周玉清,曹玲生,卢永,夏伟,殷大鹏,陈园生,李黎,梁晓峰.2004年全国计划免疫审评不同免疫覆盖率县的儿童脊髓灰质炎中和抗体水平调查[J].中国计划免疫,2006,12(6):454-458. 被引量:36
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  • 9黄秀敏,林献丹,陈佩,李倩,严菊英,蒋德媚,刘丽琳.浙江省温州市瓯海区健康人群脊髓灰质炎抗体水平监测分析[J].疾病监测,2008,23(4):221-223. 被引量:8
  • 10龚成,张铁钢,罗明,张合润,李仁清,王玉梅,陈萌,董梅,陈维新,张朱佳子,陈丽娟.北京市发现输入性脊髓灰质炎野病毒健康携带者[J].中华预防医学杂志,2012,46(8):764-765. 被引量:3

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