摘要
目的：系统评价当总前列腺特异性抗原（PSA）处于诊断灰区（4-10μg/L）时,游离PSA/总PSA（f/tPSA）与前列腺特异抗原密度（PSAD）对前列腺癌的诊断价值。方法：利用计算机检索Cochrane图书馆、PubMed、中国生物医学文献数据库等中外文数据库,收集有关利用f/tPSA和PSAD诊断前列腺癌的文献,采用QUADAS进行质量评价,用MetaDisc1.4软件进行Meta分析。结果：共纳入7篇文献,1013例患者。f/tPSA和PSAD诊断前列腺癌的敏感度分别为0.78、0.79,特异度分别为0.54、0.57,两者的综合受试者工作特征曲线下面积分别为0.7761和0.7821,Q指数分别为0.7153和0.7204。结论：总PSA处于4-10μg/L时,f/tPSA与PSAD对前列腺癌的诊断效能无明显差异。
Objective：To systematically assess the diagnostic value of free prostate-specific antigen /total prostate-specific antigen （f/tPSA） and prostate specific antigen density （PSAD） for prostate cancer in patients with tPSA level of 4-10 μg/L. Methods：The databases of Cochrane Library,PubMed,Chinese Biomedical Literature Database were retrieved for f/t PSA and PSAD in the diagnosis of prostate cancer. The quality of included trials was assessed according to QUADAS items. The software MetaDisc1.4 was used for data analysis. Results：A tota1 of 7 researches involved 1013 patients were included. The pooled accuracy indicators of sensitivity and specificity of f/tPSA and PSAD were 0.78, 0.79 and 0.54, 0.57, respectively. The area under curve of SROC curve of f/tPSA and PSAD were 0.776 1 and 0.782 1, in which Q index were 0.715 3 and 0.720 4.Conclusion：When the PSA is 4-10 μg/L, there is no significant difference in prostate cancer diagnosis using f/tPSA or PSAD.
出处
《天津医药》
CAS
北大核心
2012年第3期273-276,共4页
Tianjin Medical Journal
关键词
前列腺肿瘤
前列腺增生
前列腺特异抗原
META分析
诊断
prostatic neoplasms prostatic hyperplasia prostate-specific antigen Meta-analysis diagnosis
