视黄醇结合蛋白4与2型糖尿病骨代谢的关系被引量：1

Serum retinol binding protein 4 and bone metabolism in patients with type 2 diabetes

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摘要目的:探讨血清视黄醇结合蛋白4(RBP4)与2型糖尿病(T2DM)骨转换指标骨钙素(OC)、Ⅰ型胶原C-末端交联顶端肽(CTX)及骨密度(BMD)水平的相关性。方法:128例门诊初诊T2DM患者及同期门诊或体检中心健康体检者,其中正常葡萄糖耐量(NGT)组46例和T2DM组82例,进一步分男女亚组(M-NGT,F-NGT,M-T2DM,F-T2DM)。ELISA测定血清中RBP4,OC,CTX水平;双能X线骨密度仪(DXA)测定各部位BMD。结果:T2DM组无论男性或女性,lnRBP4与lnCTX均存在显著正相关(M-T2DM,r=0.564,P<0.01;F-T2DM,r=0.386,P=0.018),与lnOC不相关;校正年龄、吸烟、血肌酐清除率(CCr)、腰臀比后,M-T2DM的正相关仍显著(r=0.536,P<0.01),而F-T2DM组lnRBP4与lnCTX相关性消失(r=0.317,P=0.072)。NGT组,lnRBP4与lnOC及lnCTX无相关性;无论NGT组还是T2DM组,lnRBP4与各部位BMD均不相关。结论:T2DM患者的血清RBP4可能与骨代谢相关。 Objective：To determine the relation between serum concentration of retinol binding protein （RBP） 4 and markers of bone metabolism, bone mineral density （BMD） in patients with type 2 diabetes mellitus （T2DM）. Methods： A total of 82 patients newly diagnosed with T2DM and 46 subjects with normal glucose tolerance （NGT） enrolled in the cross-sectional study. Subset analyses were performed, dividing subjects on the basis of gender into M-T2DM, F-T2DM, M-NGT, and F-NGT. The serum concentrions of RBP4, osteocalcin （OC） and C-terminal telopeptide of collagen type Ⅰ （CTX） were measured with ELISA. The BMD was measured by dual-energy X-ray absorptiometry （DXA） with a Hologic QDR4500A device. Results： In both the T2DM groups, lnRBP4 showed a positive relationship with lnCTX （M-T2DM, r=0.564, P〈0.01; F-T2DM, r=0.386, P=0.018）, but no association with lnOC. After adjusting for age, smoking, creatinine clearance rate （CCr）, and waist-to-hip ratio （WHR）, lnRBP4 still showed a strong association with lnCTX in the M-T2DM group （r =0.536, P〈0.01）, but not in F-T2DM （r =0.317, P=0.072）. In the NGT group, there was no relation between lnRBP4 and lnCTX or lnOC. LnRBP4 showed no association with BMD in all groups.Conclusion：The level of serum RBP4 may be correlated with the bone metabolism in patients withT2DM.

作者叶爱玲张红彭依群廖二元

机构地区中南大学湘雅二医院代谢内分泌研究所浙江省台州医院内分泌科

出处《中南大学学报（医学版）》 CAS CSCD 北大核心 2012年第2期197-202,共6页 Journal of Central South University ：Medical Science

关键词 2型糖尿病视黄醇结合蛋白4 骨钙素 Ⅰ型胶原C-末端交联顶端肽骨密度 type 2 diabetes mellitus retinol binding protein 4 osteocalcin C-terminal telopeptide of collagen type 1 bone mineral density .

分类号 R580 [医药卫生—内分泌] R587.1 [医药卫生—内分泌]

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