摘要
以可压性、崩解时间及口感为指标,筛选了不含药的吲达帕胺口崩片处方。采用湿法制粒工艺制备载药片剂,并测定其崩解时间及溶出度。结果表明,采用优化工艺制备的吲达帕口崩片平均崩解时间在30 s内。与普通片相比,本品在10 min内能基本释放完全。
The formulation of orally disintegrating tablets without indapamide were screened with compressibility, disintegration time and taste as indexes. The tablets loaded with indapamide were prepared by wet granulation, and the disintegration time and dissolution were determined. The results showed that the average disintegration time of optimal tablets was within 30 s. Compared with common tablets, the product could completely release within 10 rain.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2012年第3期191-193,200,共4页
Chinese Journal of Pharmaceuticals
关键词
吲达帕胺
口崩片
崩解时间
溶出度
indapamide
orally disintegrating tablet
disintegrating time
dissolution
