摘要
目的探讨丹田降脂丸对小鼠耳廓微循环的影响。方法以辛伐他汀作为阳性药,采用PeriFlux system5000激光多普勒血流仪观测丹田降脂丸分别对小鼠耳廓微循环在正常状态和肾上腺素所致微循环障碍状态下的血流灌注量(PU)的影响。结果与空白对照组比较,丹田降脂丸高、中、低各剂量组均可显著增加正常状态下的小鼠耳廓血流灌注量(P<0.01),并可明显减轻肾上腺素所致的微血管收缩反应,改善微循环障碍(P<0.01)。结论丹田降脂丸可有效改善正常小鼠和肾上腺素致所致微循环障碍小鼠耳廓微循环。
Objective To explore the effect of Dantian Jiangzhi Pill on auricular PeriFlux system 5000 laser doppler cycler was used to measure the blood perfusion microcirculation in mice. Methods unit （PU） of mice auricle in both normal condition and microcirculation disturbance condition induced by adrenaline. Simvastatin was used as the posi- tive drug. Results Compared with the blank control group, high, moderate and lowdosage Dantian Jiangzhi Pill increased blood perfusion unit of mice auricle significantly in normal condition（P 〈 0.01 ）, and alleviated microvas- cular contraction and improved microcirculation disturbance induced by adrenaline（P 〈 0.01 ）. Conclusion Dantian Jiangzhi Pill could effectively improve auricular microcirculation in normal mice and in adrenaline-induced microcir culation disturbance mice.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2012年第2期164-166,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广州中医药大学创新基金(11CX023)
广东省科技计划项目(2009A030100014)
关键词
丹田降脂丸
耳廓微循环
血流灌注量
Dantian Jiangzhi Pill
Auricular microcirculation
Blood perfusion unit
