摘要
哺乳动物雷帕霉素靶蛋白（mTOR）在调节细胞增殖、生长、能量代谢等方面起重要作用，在很多肿瘤中表达过量，通过mTOR抑制剂雷帕霉素等可以起到抑制胃癌发展的作用。联合mTOR上下游通路研究对胃癌的早期诊断、监测疗效及预后价值更大。
Mammalian target of rapamycin （mTOR） plays an important role in the regulation of cell proliferation, growth, energy metabolism and so on. Clinical research demonstrate that many tumors have its excessive expression, and the mTOR inhibitors rapamycin can resist the development of gastric cancer. Research of mTOR signaling pathway combined with its upstream and downstream has larger value for the early diagnosis, monitoring curative effect and prognosis.
出处
《国际肿瘤学杂志》
CAS
2012年第3期222-224,共3页
Journal of International Oncology
