摘要
研究了ＳＯ_２在体内的衍生物一亚硫酸氢钠和亚硫酸钠对中国仓鼠肺纤维细胞（ＣＨＬ）细胞染色体畸变（ＣＡ）的诱发作用研究结果表明，ＳＯ_２的衍生物不论是否有Ｓ_９混合物的存在情况下，均可诱发ＣＨＬ细胞的ＣＡ频率显著增高，且呈明确的剂量一效应关系．这说明ＳＯ_２不需要体内代谢转化的直接的细胞染色体断裂剂和基因毒性因子研究亦发现，ＳＯ_２产低浓度下主要诱发染色单体型畸变，在高浓度下既可引起染色单体型畸变，又可引起染色体型畸变研究还发现，ＳＯ_２衍生物处理细胞时间愈长，引起细胞遗传损伤所需的最低浓度就越低．提示：长期接触环境低浓度ＳＯ_２污染，有引起接触人群体内细胞遗传物质损伤的潜在危险。
Induction effects of the in vivo derivatives of sulfur dioxide (SO_2),i.e.(bi)sulfite on chromosomal aberration (CA) in Chinese hamster fibroblast cell line (CHL cells) were investigated. Results show that the derivatives of SO_2 both in presence and unpresence of S_9 mixture may increase the frequencies of CA in CHL cells in dose-dependent manner. It implies that SO_2,which needs not to be metabolited in vivo,is a direct clastogenetic and genotoxic agent Results also show that SO_2 at low concentrations induces only chromatid-type CA, at high concentration induces both chromatid-type and chromosome-type CA, and also indicate that the lowest concentration of the chemical to cause the cytogenetic damage is lower with the bine the cells exposed to (hi)sulfite. It implies that long-exposing to SO_2 pollutant at low concentration in air environment may be a potential risk to induce damage of cytogenetic material in vivo for human beings.
出处
《中国环境科学》
EI
CAS
CSSCI
CSCD
北大核心
2000年第1期8-12,共5页
China Environmental Science
基金
国家自然科学基金!39770634
山西省自然科学基金!991069
关键词
二氧化硫
亚硫酸氢钠
CHL细胞
染色体畸变
sulfur dioxide； bisulfite； CHL cells
chromosomal aberration
S_9 mixture
