摘要
目的对左旋肉碱治疗非酒精性脂肪肝的有效性及安全性进行评价方法系统检索相关文献,根据纳入标准筛选后对纳入的研究进行评价和Meta分析。结果总有效率、总胆固醇降低量、甘油三酯降低量等指标,左旋肉碱单用组的结果差异无统计学意义,联合用药组的结果差异具有统计学意义。丙氨酸氨基转移酶降低量、天门冬酸氨基转移酶降低量等指标,单用组及联合用药组的结果差异均具有统计学意义。两组不良反应发生率的差异无统计学意义。结论左旋肉碱治疗非酒精性脂肪肝安全有效,但需联合其他阳性药物才能更好地发挥作用。
Objective To assess the efficiency and safety of L-carnitine for nonalcoholic fatty liver disease. Methods Searching for all the relative references, and to select the references according to the inclusion criterion, then to appraise them critically and conduct Metaanalysis. Results The total effective rate,TC decrease,TG decrease of L- carnitine single group has no statistical significance, while drug combination group has statistical significance. ALT decrease, AST decrease of Both the L- carnitine sinlge gruop and drug combination group have statistical significance. There is no statistically significant difference in the category of the incidence of advert reaction. Conclusion L-carnitine is effective and safe for nonalcoholic fatty liver disease, given that it is combined with other positive agent for better impact.
出处
《中国药业》
CAS
2012年第5期4-8,共5页
China Pharmaceuticals
关键词
左旋肉碱
非酒精性脂肪肝
系统评价
META分析
L - carnitine
nonalcoholic fatty liver disease
systematic review
Meta - analysis
