摘要
目的探讨尿毒症维持性血液透析(MHD)患者血浆可溶性血管细胞黏附分子-1(sVCAM-1)的变化及其意义。方法应用酶联免疫吸附试验(ELISA)法测定48例尿毒症维持性血液透析患者(MHD组)和20例健康志愿者(对照组)血浆sVCAM-1、CRP和sCD40L的水平。结果 MHD组血浆sVCAM-1、CRP和sCD40L的水平均明显高于对照组(P<0.01),MHD伴冠心病组sVCAM-1、CRP和sCD40L水平明显高于不伴冠心病组(P<0.01);直线相关分析表明sVCAM-1水平与CRP呈正相关(r=0.413,P<0.01),与sCD40L呈正相关(r=0.368,P<0.05)。结论 MHD患者尤其是合并冠心病患者sVCAM-1的水平升高,可能参与动脉粥样硬化的形成。
Objective To investigate the changes of plasma soluble vascular cell adhesion molecule-1（sVCAM-1） and its significance in uremic patients undergoing maintenance hemodialysis（MHD）.Methods Enzyme-linked Immunosorbent Assay was used to measure the plasma sVCAM-1,CRP and sCD40L in maintenance hemodialysis patients（MHD group,n=48） and healthy volunteers（control group,n=22）.Results The levels of sVCAM-1,CRP and sCD40L were significantly higher in MHD patients than those in control（P0.01）,and the levels of sVCAM-1,CRP and sCD40L were also higher in MHD patients with coronary heart disease（CHD） than those without CHD（P0.01）.The linear correlation analysis showed that sVCAM-1 level was positively related to CRP（r=0.413,P0.01） and sCD40L（r=0.368,P0.05）.Conclusion The elevated levels of sVCAM-1 in MHD patients,particularly in those with CHD,suggested the possible relation to the pathogenesis of atherosclerosis.
出处
《医学研究杂志》
2012年第2期45-47,共3页
Journal of Medical Research
