摘要
目的观察阿德福韦酯联合苦参素胶囊治疗乙型肝炎肝硬化疗效以及对患者HBVDNA载量的影响。方法 260例乙型肝炎肝硬化患者随机分为治疗组和对照组。治疗组140例给予阿德福韦酯10mg/次,1次/d,苦参素胶囊每次0.3g,3次/d口服;对照组120例给予苦参素胶囊每次0.3g,3次/d口服。两组疗程均为48周。每12周检测1次患者肝功能、乙型肝炎病毒血清学标志物及HBVDNA载量。结果治疗组用药48周后HBVDNA低于检测下限的比率及ALT复常率显著优于对照组。结论阿德福韦酯联合苦参素胶囊治疗乙型肝炎肝硬化疗效较好,建议长期服用。
Objective To evaluate the effects of adefovir dipivoxil combined with Marine Capsules on hepatitis B virus （HBV） replication in patients with liver cirrhosis of hepatitis B. Methods Total of 260 patients with liver cirrhosis of hepatitis B were randomly divided into control group （n = 120） and treatment group （n = 140）. The treatment group received adefovir dipivoxil 10 mg once daily and Marine Capsules 300 mg three times daily, while those in control group received Marine Capsules 300 mg three times daily. The period of treatment was 48 weeks. Liver function test and serum markers of HBV were detected every 12 weeks. Results HBV DNA levels of patients in both groups were significantly different （ P 〈 0.05 ）. At the end of treatment, of undetectable ratio HBV DNA and ALT normalization rate of the treatment group were significantly higher than that in control group. Conclusions Adefovir dipivoxil in combination with Marine Capsules can significantly improve efficacy which was proposed to use for a long period.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2012年第1期46-48,共3页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
关键词
肝炎
乙型
慢性
肝硬化
抗病毒药
阿德福韦酯
Hepatitis B, chronic
Liver cirrhosis
Antiviral agents
Adefovir dipivoxil
